Healing of dehiscence defects following root surface demineralization with tetracycline: A histologic study in monkeys

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dc.contributor.authorNagata, MJH
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorLeite, C. M.
dc.contributor.authorMelo, LGN
dc.contributor.authorSundefeld, MLMM
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:29:06Z
dc.date.available2014-05-20T15:29:06Z
dc.date.issued2005-06-01
dc.description.abstractBackground: the purpose of this study was to histologically evaluate the healing of experimental dehiscence defects after surface demineralization with tetracycline hydrochloride.Methods: Six adult male monkeys (Cebus apella) were used in this study. Dehiscence defects were surgically created on the buccal aspect of the mandibular lateral incisors in all animals. The root surfaces were debrided and planed. In a split-mouth design, a 10% tetracycline hydrochloride solution was applied to one tooth for 4 minutes (T group), followed by irrigation with saline. The contralateral tooth served as a control (C group). The flaps were repositioned and sutured. The animals were sacrificed at 6 months postoperatively and histological sections were processed. Computer-assisted histomorphometric analysis was used to evaluate the formation of new cementum, new bone, new connective tissue attachment, and length of the epithelium (junctional and sulcular).Results: Bone regeneration was similar in both groups (1.5 +/- 0.3 mm for the T group and 1.5 +/- 0.6 mm for the C group). The C group showed more new cementum than the T group (2.3 +/- 0.3 mm versus 2.2 +/- 0.3 mm) as well as a longer epithelium (1.0 +/- 0.3 mm versus 0.9 +/- 0.2 mm). The T group presented more new connective tissue attachment (3.1 +/- 0.2 mm) than the C group (2.9 +/- 0.6 mm). However, no statistically significant differences were detected between the two groups.Conclusions: the amount of new attachment was similar in both groups. Root conditioning with 10% tetracycline solution did not produce any additional new attachment in comparison to the controls.en
dc.description.affiliationUNESP, Dept Surg, Aracatuba, SP, Brazil
dc.description.affiliationUNESP, Integrated Clin, Dent Sch Aracatuba, Aracatuba, SP, Brazil
dc.description.affiliationUNESP, Dept Prevent Dent, Dent Sch Aracatuba, Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Surg, Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP, Integrated Clin, Dent Sch Aracatuba, Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Prevent Dent, Dent Sch Aracatuba, Aracatuba, SP, Brazil
dc.format.extent908-914
dc.identifierhttp://dx.doi.org/10.1902/jop.2005.76.6.908
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 76, n. 6, p. 908-914, 2005.
dc.identifier.doi10.1902/jop.2005.76.6.908
dc.identifier.issn0022-3492
dc.identifier.lattes8399870097572073
dc.identifier.lattes9831236034935598
dc.identifier.urihttp://hdl.handle.net/11449/38767
dc.identifier.wosWOS:000229953600006
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanimal studiespt
dc.subjectbone, demineralizedpt
dc.subjectperiodontal attachmentpt
dc.subjectperiodontal regenerationpt
dc.subjecttetracycline/therapeutic usept
dc.subjecttooth/anatomy and histologypt
dc.titleHealing of dehiscence defects following root surface demineralization with tetracycline: A histologic study in monkeysen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/userimages/ContentEditor/1124388816475/Instructions_to_Authors.pdf
dcterms.rightsHolderAmer Acad Periodontology
unesp.author.lattes8399870097572073
unesp.author.lattes9831236034935598
unesp.author.orcid0000-0002-4476-6695[3]
unesp.author.orcid0000-0001-5903-5652[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Cirurgia e Clínica Integrada - FOA