Inclusion complex of S(-) bupivacaine and 2-hydroxypropyl-β-cyclodextrin: study of morphology and cytotoxicity

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dc.contributor.authorMoraes, C. M.
dc.contributor.authorAraújo, D. R.
dc.contributor.authorIssa, M. G.
dc.contributor.authorFerraz, H. G.
dc.contributor.authorYokaichiya, F.
dc.contributor.authorFranco, M. K. K. D.
dc.contributor.authorMazzaro, I.
dc.contributor.authorLopes, P. S.
dc.contributor.authorGonçalves, M. M.
dc.contributor.authorPaula, E. DE
dc.contributor.authorFraceto, L. F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de Sorocaba (UNISO)
dc.date.accessioned2014-06-24T19:55:13Z
dc.date.available2014-06-24T19:55:13Z
dc.date.issued2006
dc.description.abstractLocal anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-) bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in 2-hydroxypropyl-ß-cyclodextrin (HP-ß-CD). Differential scanning calorimetry, scanning electron microscopy and X-Ray diffraction analysis showed structural changes in the complex. In preliminary toxicity studies, the cell viability tests revealed that the inclusion complex decreased the toxic effect (p<0.001) produced by S(-) bvc. These results suggest that the S(-) bvc:HP-ß-CD inclusion complex represents a promising agent for the treatment of regional pain. Keywords: S(-) bupivacaine; cyclodextrin; inclusion complex.en
dc.description.affiliationDepartament of Biochemisty, State University of São Paulo, UNESP, Sorocaba, SP, Brazil.
dc.description.affiliationDepartament of Physics, Federal University of Paraná, Curitiba, PR, Brazil.
dc.description.affiliationDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, USP,
dc.description.affiliationUnespDepartament of Biochemisty, State University of São Paulo, UNESP, Sorocaba, SP, Brazil.
dc.identifierhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/383
dc.identifier.citationRevista de Ciências Farmacêuticas Básica e Aplicada, v. 27, n. 3, 2006, p. 207-212.
dc.identifier.fileISSN1808-4532-2006-27-3-207-212.pdf
dc.identifier.issn1808-4532
dc.identifier.issn2179-443X
dc.identifier.urihttp://hdl.handle.net/11449/108310
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.relation.ispartofRevista de Ciências Farmacêuticas Básica e Aplicada
dc.relation.ispartofsjr0,131
dc.rights.accessRightsAcesso aberto
dc.sourceRevista de Ciências Farmacêuticas Básica e Aplicada
dc.subjectS(-) bupivacainept
dc.subjectcyclodextrinpt
dc.subjectinclusion complexpt
dc.subjectFarmacotécnicapt
dc.titleInclusion complex of S(-) bupivacaine and 2-hydroxypropyl-β-cyclodextrin: study of morphology and cytotoxicityen
dc.typeArtigo
dcterms.licensehttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/about
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Sorocabapt

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