Fructose-rich diet leads to reduced aerobic capacity and to liver injury in rats

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dc.contributor.authorBotezelli, Jose Diego [UNESP]
dc.contributor.authorCambri, Lucieli Teresa [UNESP]
dc.contributor.authorGhezzi, Ana Carolina [UNESP]
dc.contributor.authorDalia, Rodrigo Augusto [UNESP]
dc.contributor.authorVoltarelli, Fabricio Azevedo
dc.contributor.authorRostom de Mello, Maria Alice [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Mato Grosso
dc.date.accessioned2013-09-30T18:49:32Z
dc.date.accessioned2014-05-20T13:58:54Z
dc.date.available2013-09-30T18:49:32Z
dc.date.available2014-05-20T13:58:54Z
dc.date.issued2012-06-19
dc.description.abstractThe main purpose of this research was to investigate the alterations in the aerobic capacity and appearance of metabolic alterations in Wistar rats fed on fructose-rich diet. We separated twenty-eight rats into two groups according to diet: a control group (C) (balanced diet) and a fructose-rich diet group (F). The animals were fed these diets for 60 d (d 120 to 180). We performed insulin, glucose as well as a minimum lactate test, at d 120 and 180. At the end of the experiment, sixteen animals were euthanized, and the following main variables were analysed: aerobic capacity, the serum aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, serum and liver triglyceride concentrations, serum and liver thiobarbituric acid reactive substance (TBARS) concentrations, serum and liver catalase and superoxide dismutase (SOD) activity and haematoxylin-eosin histology (HE) in hepatocytes. The remaining twelve animals were submitted to an analysis of their hepatic lipogenic rate. The animals fed a fructose-rich diet exhibited a reduction in aerobic capacity, glucose tolerance and insulin sensitivity and increased concentrations of triglycerides and TBARS in the liver. Catalase and SOD activities were reduced in the livers of the fructose-fed animals. In addition, the serum AST/ALT ratio was higher than that of the C group, which indicates hepatic damage, and the damage was confirmed by histology. In conclusion, the fructose-rich diet caused significant liver damage and a reduction in insulin sensitivity in the animals, which could lead to deleterious metabolic effects.en
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Phys Educ, BR-13506900 São Paulo, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Dept Phys Educ, Grosso, MT, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Phys Educ, BR-13506900 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 09/15336-9
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/1476-511X-11-78
dc.identifier.citationLipids In Health and Disease. London: Biomed Central Ltd., v. 11, p. 9, 2012.
dc.identifier.doi10.1186/1476-511X-11-78
dc.identifier.fileWOS000309873000001.pdf
dc.identifier.issn1476-511X
dc.identifier.urihttp://hdl.handle.net/11449/20914
dc.identifier.wosWOS:000309873000001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofLipids in Health and Disease
dc.relation.ispartofjcr2.663
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectFructoseen
dc.subjectLiver injuryen
dc.subjectOxidative stressen
dc.subjectRatsen
dc.titleFructose-rich diet leads to reduced aerobic capacity and to liver injury in ratsen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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