Cathodic stripping voltammetric determination of ceftazidime in urine at a hanging mercury drop electrode

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dc.contributor.authorFerreira, V. S.
dc.contributor.authorZanoni, Maria Valnice Boldrin [UNESP]
dc.contributor.authorFogg, A. G.
dc.contributor.institutionLOUGHBOROUGH UNIV TECHNOL
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:19:46Z
dc.date.available2014-05-20T15:19:46Z
dc.date.issued1997-09-01
dc.description.abstractA method was developed for the differential-pulse cathodic stripping voltammetric determination of ceftazidime with a hanging mercury drop electrode using its reduction peak at -0.43 V in Britton-Robinson buffer pH 4.0. The optimum accumulation potential and time were -0.15 V and up to 60 s, respectively. Linear calibration graphs were obtained from 1 x 10(-8) M and 1.5 x 10(-7) M. The limit of determination was calculated to be 5 x 10(-9) M. The coefficient of variation was 4% (n = 7) at 1 x 10(-7) M ceftazidime. The effect of various components of urine on the voltammetric response was studied, and creatinine, uric acid, urea, and glucose were shown to interfere in the method. Ceftazidime bound to human albumin gives a unique stripping peak at -0.48 V. Recoveries of 87% +/- 2% of the ceftazidime (n = 5) were obtained from urine spiked with 1.27 mu g ml(-1) using C-18 solid phase extraction cartridges. (C) 1997 Academic Press.en
dc.description.affiliationLOUGHBOROUGH UNIV TECHNOL,DEPT CHEM,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND
dc.format.extent115-122
dc.identifierhttp://dx.doi.org/10.1006/mchj.1997.1516
dc.identifier.citationMicrochemical Journal. San Diego: Academic Press Inc. Jnl-comp Subscriptions, v. 57, n. 1, p. 115-122, 1997.
dc.identifier.doi10.1006/mchj.1997.1516
dc.identifier.issn0026-265X
dc.identifier.orcid0000-0002-2296-1393
dc.identifier.urihttp://hdl.handle.net/11449/31161
dc.identifier.wosWOS:A1997YG64600012
dc.language.isoeng
dc.publisherAcademic Press Inc. Jnl-comp Subscriptions
dc.relation.ispartofMicrochemical Journal
dc.relation.ispartofjcr2.746
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCathodic stripping voltammetric determination of ceftazidime in urine at a hanging mercury drop electrodeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc. Jnl-comp Subscriptions
unesp.author.orcid0000-0002-2296-1393[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Analítica - IQ