Genome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattle

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dc.contributor.authorUtsunomiya, Yuri T. [UNESP]
dc.contributor.authorCarmo, Adriana S. [UNESP]
dc.contributor.authorNeves, Haroldo H. R. [UNESP]
dc.contributor.authorCarvalheiro, Roberto [UNESP]
dc.contributor.authorMatos, Marcia C. [UNESP]
dc.contributor.authorZavarez, Ludmilla B. [UNESP]
dc.contributor.authorIto, Pier K. R. K. [UNESP]
dc.contributor.authorO'Brien, Ana M. Perez
dc.contributor.authorSoelkner, Johann
dc.contributor.authorPorto-Neto, Laercio R.
dc.contributor.authorSchenkel, Flavio S.
dc.contributor.authorMcEwan, John
dc.contributor.authorCole, John B.
dc.contributor.authorSilva, Marcos V. G. B. da
dc.contributor.authorVan Tassell, Curtis P.
dc.contributor.authorSonstegard, Tad S.
dc.contributor.authorGarcia, José Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGenSys Consultores Associados
dc.contributor.institutionBOKU Univ Nat Resources & Life Sci
dc.contributor.institutionCSIRO Commonwealth Sci & Ind Res Org
dc.contributor.institutionUniversity of Guelph
dc.contributor.institutionAgResearch
dc.contributor.institutionARS
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2014-12-03T13:10:41Z
dc.date.available2014-12-03T13:10:41Z
dc.date.issued2014-02-18
dc.description.abstractThe reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility.en
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Ciencias Agr & Vet, Dept Med Vet Prevent & Reprod Anim, Sao Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Zootecnia, Sao Paulo, Brazil
dc.description.affiliationGenSys Consultores Associados, Porto Alegre, RS, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Med Vet Aracatuba, Dept Apoio Saude & Prod Anim, Sao Paulo, Brazil
dc.description.affiliationBOKU Univ Nat Resources & Life Sci, Div Livestock Sci, Dept Sustainable Agr Syst, Vienna, Austria
dc.description.affiliationCSIRO Commonwealth Sci & Ind Res Org, Food Futures Flagship, Brisbane, Qld, Australia
dc.description.affiliationUniv Guelph, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1, Canada
dc.description.affiliationAgResearch, Ctr Reprod & Genom, Mosgiel, Otago, New Zealand
dc.description.affiliationARS, Anim Improvement Programs Lab, USDA, Beltsville, MD USA
dc.description.affiliationEmbrapa Dairy Cattle, Bioinformat & Anim Genom Lab, Juiz De Fora, MG, Brazil
dc.description.affiliationARS, Bovine Funct Genom Lab, USDA, Beltsville, MD USA
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Ciencias Agr & Vet, Dept Med Vet Prevent & Reprod Anim, Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Zootecnia, Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Med Vet Aracatuba, Dept Apoio Saude & Prod Anim, Sao Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 560922/2010-8
dc.description.sponsorshipIdCNPq: 483590/2010-0
dc.description.sponsorshipIdFAPESP: 11/16643-2
dc.description.sponsorshipIdFAPESP: 10/52030-2
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0088561
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 2, 9 p., 2014.
dc.identifier.doi10.1371/journal.pone.0088561
dc.identifier.fileWOS000331706700046.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes9991374083045897
dc.identifier.urihttp://hdl.handle.net/11449/112401
dc.identifier.wosWOS:000331706700046
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleGenome-Wide Mapping of Loci Explaining Variance in Scrotal Circumference in Nellore Cattleen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.lattes9991374083045897
unesp.author.orcid0000-0002-6526-8337[1]
unesp.author.orcid0000-0003-4801-6207[12]
unesp.author.orcid0000-0002-8416-2087[15]
unesp.author.orcid0000-0003-1242-4401[13]
unesp.author.orcid0000-0002-3536-8265[10]
unesp.author.orcid0000-0002-4506-0555[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt

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Artigos - Apoio, Produção e Saúde Animal - FMVA