Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats

Página do item simplificado
dc.contributor.authorPortes, Leslie Andrews
dc.contributor.authordos Santos, Alexandra Alberta
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorOliveira, Natália Cristina de
dc.contributor.authorSerra, Andrey Jorge
dc.contributor.authorTucci, Paulo J. F.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T14:03:32Z
dc.date.available2023-07-29T14:03:32Z
dc.date.issued2022-08-22
dc.description.abstractAim: To evaluate the influence of swimming training on calcium responsiveness of the myocardium of rats with different infarction sizes (MI). Method: female Wistar rats, sedentary sham (SS = 14), sedentary moderate MI (SMI = 8) and sedentary large MI (SLI = 10) were compared to trained sham (TS = 16), trained moderate MI (TMI = 9) and trained large MI (TLI = 10). After 4 weeks of MI, the animals swam for 60 min/day, 5 days/week, for additional 8 weeks. Papillary muscles of the left ventricle were subjected to different concentrations of extracellular calcium. Inotropism was evaluated through the developed tension (DT), the maximum positive value of the first temporal derivation (+Td/td) and the time to peak tension (TPT). Lusitropism was evaluated by the maximum negative value of the first temporal derivation (−Td/td) and time to 50% relaxation (50%TR). Statistical significance was determined using multivariate analysis of variance and a Hotelling T2 test for the absolute power values of all four extracellular calcium concentrations (p < 0.05). Results: MI depressed inotropism (from 17% to 51%) and lusitropism (from 22% to 54%) of the sedentary rats, but exercise attenuated the losses, especially regarding + dT/dt, TPT, −dT/dt and 50%TR. Exercise attenuated the decrease in myocardial responsiveness, proportionally to the size of the MI. Conclusion: Myocardial calcium responsiveness is favorably affected in animals with moderate and large MI after swimming exercise.en
dc.description.affiliationProfessor at UNASP Researcher at LAFEX Laboratory of Exercise Physiology Adventist University of Sao Paulo
dc.description.affiliationLaboratory of Cardiac Physiology and Cardiovascular Physiopathology Federal University of Sao Paulo
dc.description.affiliationDepartment of Biostatistics Bioscience Institute UNESP-State University of Sao Paulo
dc.description.affiliationMaster Degree Program in Health Promotion UNASP-Adventist University of São Paulo
dc.description.affiliationUnespDepartment of Biostatistics Bioscience Institute UNESP-State University of Sao Paulo
dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.923603
dc.identifier.citationFrontiers in Physiology, v. 13.
dc.identifier.doi10.3389/fphys.2022.923603
dc.identifier.issn1664-042X
dc.identifier.scopus2-s2.0-85137841772
dc.identifier.urihttp://hdl.handle.net/11449/249143
dc.language.isoeng
dc.relation.ispartofFrontiers in Physiology
dc.sourceScopus
dc.subjectcalcium responsivity
dc.subjectexercise training
dc.subjectinoprotpism
dc.subjectlusitropism
dc.subjectmyocardial infarction
dc.subjectrats
dc.subjectswimming exercise
dc.titleSwimming training attenuates the decrease of calcium responsiveness in female infarcted ratsen
dc.typeArtigo

Arquivos

Coleções

Artigos - Bioestatística - IBB