Role of pressor mechanisms from the NTS and CVLM in control of arterial pressure

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dc.contributor.authorMoreira, T. S.
dc.contributor.authorSato, M. A.
dc.contributor.authorTakakura, ACT
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:45:39Z
dc.date.available2014-05-20T13:45:39Z
dc.date.issued2005-11-01
dc.description.abstractIn the present study, we investigated the effects of inhibition of the caudal ventrolateral medulla (CVLM) with the GABA(A) agonist muscimol combined with the blockade of glutamatergic mechanism in the nucleus of the solitary tract (NTS) with kynurenic acid (kyn) on mean arterial pressure (MAP), heart rate (HR), and regional vascular resistances. In male Holtzman rats anesthetized intravenously with urethane/chloralose, bilateral injections of muscimol (120 pmol) into the CVLM or bilateral injections of kyn (2.7 nmol) into the NTS alone increased MAP to 186 +/- 11 and to 142 +/- 6 mmHg, respectively, vs. control: 105 +/- 4 mmHg; HR to 407 +/- 15 and to 412 +/- 18 beats per minute (bpm), respectively, vs. control: 352 +/- 12 bpm; and renal, mesenteric and hindquarter vascular resistances. However, in rats with the CVLM bilaterally blocked by muscimol, additional injections of kyn into the NTS reduced MAP to 88 +/- 5 mmHg and mesenteric and hindquarter vascular resistances below control baseline levels. Moreover, in rats with the glutamatergic mechanisms of the NTS blocked by bilateral injections of kyn, additional injections of muscimol into the CVLM also reduced MAP to 92 +/- 2 mmHg and mesenteric and hindquarter vascular resistances below control baseline levels. Simultaneous blockade of NTS and CVLM did not modify the increase in HR but also abolished the increase in renal vascular resistance produced by each treatment alone. The results suggest that important pressor mechanisms arise from the NTS and CVLM to control vascular resistance and arterial pressure under the conditions of the present study.en
dc.description.affiliationUniv Fed São Paulo, Dept Physiol, EPM, São Paulo, Brazil
dc.description.affiliationUNESP, Fac Odontol, Dept Physiol & Pathol, Araraquara, Brazil
dc.description.affiliationABC, Fac Med, Dept Physiol, Santo Andre, Brazil
dc.description.affiliationUnespUNESP, Fac Odontol, Dept Physiol & Pathol, Araraquara, Brazil
dc.format.extentR1416-R1425
dc.identifierhttp://dx.doi.org/10.1152/ajpregu.00053.2005
dc.identifier.citationAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 289, n. 5, p. R1416-R1425, 2005.
dc.identifier.doi10.1152/ajpregu.00053.2005
dc.identifier.issn0363-6119
dc.identifier.lattes1023597870118105
dc.identifier.lattes4544450092427426
dc.identifier.urihttp://hdl.handle.net/11449/16068
dc.identifier.wosWOS:000232528200025
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.relation.ispartofjcr3.082
dc.relation.ispartofsjr1,550
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectventrolateral medullapt
dc.subjectgammapt
dc.subjectgamma-aminobutyric acidpt
dc.subjectL-glutamatept
dc.subjectmuscimolpt
dc.subjectsympathetic systempt
dc.titleRole of pressor mechanisms from the NTS and CVLM in control of arterial pressureen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes1023597870118105
unesp.author.lattes4544450092427426[5]
unesp.author.orcid0000-0002-1395-4036[5]
unesp.author.orcid0000-0003-1167-4441[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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