Cigarette smoking and high-risk HPV DNA as predisposing factors for high-grade cervical intraepithelial neoplasia (CIN) in young Brazilian women

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dc.contributor.authorRoteli-Martins, Cecilia Maria
dc.contributor.authorPanetta, Kazue
dc.contributor.authorAlves, Venancio Avancini Ferreira
dc.contributor.authorSiqueira, Sheila Aparecida Coelho
dc.contributor.authorSyrjänen, Kari Juhani
dc.contributor.authorDerchain, Sophie Françoise Mauricette
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHospital Leonor Mendes de Barros
dc.contributor.institutionUniversity of Kuopio
dc.date.accessioned2014-05-27T11:19:36Z
dc.date.available2014-05-27T11:19:36Z
dc.date.issued1998-09-19
dc.description.abstractBackground. This cross-sectional study was designed to evaluate the role of cigarette smoking and high-risk HPV types as risk factors of CIN 2 and 3 in young, sexually active Brazilian women. Materials and method. A series of 100 consecutive women with abnormal Pap smears were recruited, subjected to colposcopy, punch biopsy, and questionnaire for their social, sexual and reproductive factors. Of these, 77 women between 20 and 35 years of age (median 26.5 years) with biopsy-confirmed CIN 1 or CIN 2 and 3, were enrolled in this study. Representative samples from the exocervix and endocervix were obtained for HPV testing with the Hybrid Capture HPV-DNA assay, including the probes for the oncogenic HPV types (16, 18, 31, 33, 35, 45, 51, 52 and 56). Results. The overall rate of CIN 2 and 3 was 23/77 (29.8%). The women with CIN 1, 2 and 3 did not differ from each other with regard to their age, race, schooling, marital status, life-time number of sexual partners, age at first intercourse, use of oral contraceptives, or parity. However, current cigarette smoking was strongly associated with CIN 2 and 3 (p < 0,001), and among smokers, the risk of high-grade CIN increased in parallel with the time of exposure (years of smoking) p = 0.07), HPV-DNA of the oncogenic types was detected in 43 (56%) women, the risk of being HPV DNA-positive was significantly higher in CIN 2 and 3 as compared with CIN 1 (p = 0.037). Importantly, the prevalence of high-risk HPV types was significantly higher in cigarette smokers than in non-smokers (p = 0.046). Conclusions. The results indicate that the severity of CIN lesions was clearly related to two fundamental risk factors: 1) high-risk HPV types, and 2) current cigarette smoking. These two risk factors were closely interrelated in that the high-risk HPV types were significantly more frequent in current smokers than in non-smokers, suggesting the possibility of a synergistic action between these two risk factors in cervical carcinogenesis.en
dc.description.affiliationDept. of Obstetrics and Gynecology Campinas State University (UNICAMP), Saõ Paulo
dc.description.affiliationDepartment of Pathology Saõ Paulo State University USP, Saõ Paulo
dc.description.affiliationLeonor Mendes de Barros Hospital, São Paulo
dc.description.affiliationDepartment of Pathology University of Kuopio, Kuopio
dc.description.affiliation, Rua Juquis 273 cj 54, 04081-010 Sào-Paulo SP
dc.format.extent678-682
dc.identifierhttp://dx.doi.org/10.1034/j.1600-0412.1998.770617.x
dc.identifier.citationActa Obstetricia et Gynecologica Scandinavica, v. 77, n. 6, p. 678-682, 1998.
dc.identifier.doi10.1034/j.1600-0412.1998.770617.x
dc.identifier.issn0001-6349
dc.identifier.scopus2-s2.0-0031717220
dc.identifier.urihttp://hdl.handle.net/11449/65515
dc.identifier.wosWOS:000074642700017
dc.language.isoeng
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavica
dc.relation.ispartofjcr2.649
dc.relation.ispartofsjr1,283
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCervical intraepithelial neoplasia (CIN)
dc.subjectHuman papilloma virus (HPV)
dc.subjectRisk factor
dc.subjectSmoking
dc.subjectoral contraceptive agent
dc.subjectvirus dna
dc.subjectadult
dc.subjectbrazil
dc.subjectcancer risk
dc.subjectcancer susceptibility
dc.subjectcigarette smoking
dc.subjectcolposcopy
dc.subjecteducation
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmarriage
dc.subjectpapanicolaou test
dc.subjectparity
dc.subjectpriority journal
dc.subjectpunch biopsy
dc.subjectquestionnaire
dc.subjectrisk factor
dc.subjectsexual behavior
dc.subjectsexual intercourse
dc.subjectsocial behavior
dc.subjectuterine cervix carcinoma in situ
dc.subjectuterine endocervix
dc.subjectwart virus
dc.subjectAdult
dc.subjectBiopsy
dc.subjectBrazil
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectCross-Sectional Studies
dc.subjectDNA, Viral
dc.subjectFemale
dc.subjectHumans
dc.subjectPapillomaviridae
dc.subjectPapillomavirus Infections
dc.subjectPrevalence
dc.subjectQuestionnaires
dc.subjectRisk Factors
dc.subjectSexual Behavior
dc.subjectTumor Virus Infections
dc.subjectUterine Cervical Neoplasms
dc.subjectWomen's Health
dc.titleCigarette smoking and high-risk HPV DNA as predisposing factors for high-grade cervical intraepithelial neoplasia (CIN) in young Brazilian womenen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html

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