Effects of prolonged oral administration of fumonisin B(1) and aflatoxin B(1) in rats

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dc.contributor.authorPozzi, C. R.
dc.contributor.authorCorrea, B.
dc.contributor.authorXavier, J. G.
dc.contributor.authorDireito, G. M.
dc.contributor.authorOrsi, R. B.
dc.contributor.authorMatarazzo, S. V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Zootecnia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:23Z
dc.date.available2014-05-20T15:21:23Z
dc.date.issued2001-01-01
dc.description.abstractThe effects of prolonged oral administration (21 days) of fumonisin B(1) (FB(1)) and aflatoxin B(1) (AFB(1)) were evaluated on male Wistar rats. The animals were housed in individual metabolic cages and submitted to the following treatments: 1-0 mug AFB(1) + 0 mg FB(1)/100g bw.; 2-72 mug AFB(1)+ 0 mg FB(1)/100 g bw; 3-0 mug AFB(1) + 0.5 mg FB(1) g bw; 4-0 mug AFB(1) + 1.5 mg FB(1)/100 g bw; 5-72 mug AFB(1) + 0.5 mg FB(1)/100g bw; 6-72 mu gAFB(1) + 1.5 mg FB(1)/100g bw. on day 21, the rats were sacrificed for evaluation. The results showed that treated animals presented differences in body weight and absolute/relative weights of liver and kidney as well as altered hepatic function and cholesterol blood levels. Rats fed with the greatest doses of AFB(1) and FB(1) gained less weight (2.79 g/day) at the end of the experimental period; their blood concentrations of liver enzymes aspartate aminotransferase (AST) and alkaline phosphatase (AP) were above control levels (130.35 mu /l and 471.00 mu /l, respectively). Blood cholesterol increased in the groups treated with the highest dose of FB(1) or FB(1) associated with AFB(1). Histopathology revealed the occurrence of apoptosis in the liver of rats exposed to FB(1). The association of aflatoxin B(1) with fumonisin B(1) at higher dose probably potentiated the effects of the higher dose of fumonisin B(1)acting singly.en
dc.description.affiliationUniv São Paulo, ICB, Dept Microbiol, BR-05508900 São Paulo, Brazil
dc.description.affiliationInst Zootecnia, Ctr Nutr & Alimentacao Anim, BR-13460000 Nova Odessa, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Ciências Biomed, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Ciências Biomed, São Paulo, Brazil
dc.format.extent21-27
dc.identifierhttp://dx.doi.org/10.1023/A:1010954119980
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 151, n. 1, p. 21-27, 2001.
dc.identifier.doi10.1023/A:1010954119980
dc.identifier.issn0301-486X
dc.identifier.urihttp://hdl.handle.net/11449/32533
dc.identifier.wosWOS:000169517200005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectaflatoxinspt
dc.subjectbiological effectspt
dc.subjectfumonisinspt
dc.subjectprolonged oralpt
dc.subjectrats Wistarpt
dc.titleEffects of prolonged oral administration of fumonisin B(1) and aflatoxin B(1) in ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer

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