Sino-aortic denervation causes right atrial beta adrenoceptor down-regulation

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dc.contributor.authorZanesco, A.
dc.contributor.authorSpadariBratfisch, R. C.
dc.contributor.authorBarker, L. A.
dc.contributor.institutionLOUISIANA STATE UNIV
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionDEPT PHYSIOL & BIOPHYS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:57Z
dc.date.available2014-05-20T15:27:57Z
dc.date.issued1997-02-01
dc.description.abstractRat isolated right atria obtained 1 wk after sinoaortic denervation were less sensitive to the chronotropic actions of beta-agonists than were tissues obtained from animals that underwent sham surgery or no surgery at all. The potencies, but not the maximal responses for two high efficacy agonists, norepinephrine and isoproterenol, were reduced about 3- to 4-fold. Sinoaortic denervation (SAD) caused about a 3-fold decrease in potency and about a 60% decrease in maximal response for a low efficacy agonist, prenalterol. The changes in the actions of these agonists occurred in the absence of any changes in the subtype of beta receptor mediating the chronotropic response. The results of analyses of the data for prenalterol showed that SAD caused a decrease in the operational efficacy of this agonist without any changes in its K-D value for beta-1 adrenoceptors. SAD had no effect on the responses of the tissue to blockade of uptake 1 and uptake 2, suggesting no compensatory changes in the removal processes caused the decreased potency. The results of radioligand binding assays showed that SAD caused a decrease in the maximal binding of I-125-cyanopindolol without altering its K-D. Also, the results of competition binding assays confirmed the lack of effect of SAD on the K-D for prenalterol. The SAD-induced changes in the actions of agonists acting at right atrial beta-1 receptors were caused by a down-regulation of beta-1 adrenoceptors, which probably occurred in response to SAD-induced increases in sympathetic tone.en
dc.description.affiliationLOUISIANA STATE UNIV,MED CTR,DEPT PHARMACOL,SCH DENT,NEW ORLEANS,LA 70119
dc.description.affiliationUNIV CAMPINAS,SAO PAULO,BRAZIL
dc.description.affiliationDEPT PHYSIOL & BIOPHYS,SAO PAULO,BRAZIL
dc.description.affiliationSTATE UNIV PAULISTA,DEPT EDUC PHYS,RIO CLARO,SP,BRAZIL
dc.format.extent677-685
dc.identifierhttp://jpet.aspetjournals.org/content/280/2/677
dc.identifier.citationJournal of Pharmacology and Experimental Therapeutics. Baltimore: Williams & Wilkins, v. 280, n. 2, p. 677-685, 1997.
dc.identifier.issn0022-3565
dc.identifier.lattes4472007237545596
dc.identifier.urihttp://hdl.handle.net/11449/37868
dc.identifier.wosWOS:A1997WG58000021
dc.language.isoeng
dc.publisherWilliams & Wilkins
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeutics
dc.relation.ispartofjcr3.706
dc.relation.ispartofsjr1,586
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleSino-aortic denervation causes right atrial beta adrenoceptor down-regulationen
dc.typeArtigo
dcterms.licensehttp://jpet.aspetjournals.org/site/misc/terms.xhtml
dcterms.rightsHolderWilliams & Wilkins
unesp.author.lattes4472007237545596
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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