VEGF and MVD expression in sinus augmentation with autologous bone and several graft materials

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dc.contributor.authorBoeck-Neto, R. J. [UNESP]
dc.contributor.authorArtese, L.
dc.contributor.authorPiattelli, A.
dc.contributor.authorShibli, J. A.
dc.contributor.authorPerrotti, V.
dc.contributor.authorPiccirilli, M.
dc.contributor.authorMarcantonio, E. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv G dAnnunzio
dc.contributor.institutionUniv Guarulhos
dc.date.accessioned2013-09-30T18:31:39Z
dc.date.accessioned2014-05-20T13:45:18Z
dc.date.available2013-09-30T18:31:39Z
dc.date.available2014-05-20T13:45:18Z
dc.date.issued2009-03-01
dc.description.abstractThe aim of this study was to assess vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in maxillary sinus augmentation with autogenous bone and different graft materials for evaluating their angiogenic potential.Biopsies were harvested 10 months after sinus augmentation with a combination of autogenous bone and different graft materials: hydroxyapatite (HA, n = 6 patients), demineralized freeze-dried bone allograft (DFDBA, n = 5 patients), calcium phosphate (CP, n = 5 patients), Ricinus communis polymer (n = 5 patients) and control group - autogenous bone only (n = 13 patients).In all the samples, higher intensities of VEGF expression were prevalent in the newly formed bone, while lower intensities of VEGF expression were predominant in the areas of mature bone. The highest intensity of VEGF expression in the newly formed bone was expressed by HA (P < 0.001) and CP in relation to control (P < 0.01) groups. The lowest intensities of VEGF expression in newly formed bone were shown by DFDBA and polymer groups (P < 0.05). When comparing the different grafting materials, higher MVD were found in the newly formed bone around control, HA and CP (P < 0.001).Various graft materials could be successfully used for sinus floor augmentation; however, the interactions between bone formation and angiogenesis remain to be fully characterized.en
dc.description.affiliationState Univ São Paulo, UNESP, Dent Sch Araraquara, Dept Periodontol, Araraquara, SP, Brazil
dc.description.affiliationUniv G dAnnunzio, Sch Dent, Dept Pathol, Peacara, Italy
dc.description.affiliationUniv G dAnnunzio, Sch Dent, Dept Oral Pathol & Med, Peacara, Italy
dc.description.affiliationUniv Guarulhos, Dent Res Div, Dept Periodontol, Guarulhos, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo, UNESP, Dent Sch Araraquara, Dept Periodontol, Araraquara, SP, Brazil
dc.format.extent148-154
dc.identifierhttp://dx.doi.org/10.1111/j.1601-0825.2008.01502.x
dc.identifier.citationOral Diseases. Malden: Wiley-blackwell Publishing, Inc, v. 15, n. 2, p. 148-154, 2009.
dc.identifier.doi10.1111/j.1601-0825.2008.01502.x
dc.identifier.issn1354-523X
dc.identifier.urihttp://hdl.handle.net/11449/15925
dc.identifier.wosWOS:000263138000004
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofOral Diseases
dc.relation.ispartofjcr2.310
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectgraft materialsen
dc.subjectguided bone regenerationen
dc.subjectmaxillary sinus augmentationen
dc.subjectmicrovessel densityen
dc.subjectvascular endothelial growth factoren
dc.titleVEGF and MVD expression in sinus augmentation with autologous bone and several graft materialsen
dc.typeArtigo
dcterms.licensehttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1601-0825/homepage/ForAuthors.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.author.orcid0000-0003-1294-2305[7]
unesp.author.orcid0000-0003-1971-0195[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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