Morphofunctional evaluation of thymus in hyperglycemic-hypoinsulinemic mice during dermatophytic infection

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dc.contributor.authorVenturini, James [UNESP]
dc.contributor.authorGolim, Marjorie A. [UNESP]
dc.contributor.authorAlvares, Anuska M. [UNESP]
dc.contributor.authorLocachevic, Gisele A. [UNESP]
dc.contributor.authorArruda, Olavo S. [UNESP]
dc.contributor.authorArruda, Maria Sueli Parreira de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-20T13:25:51Z
dc.date.available2014-05-20T13:25:51Z
dc.date.issued2011-06-01
dc.description.abstractMany works have shown that the enhanced susceptibility to infection seen in diabetic patients can be related to the hyperglycemia-hypoinsulinemia (HH) observed in this condition. Herein, we evaluated the HH effects on the morphofunctional features of the thymus as well as on dermatophytic infection. We demonstrated that, not only the HH condition but also the dermatophytic infection induced transitory alterations in the thymus; it was characterized by loss of cortical-medullar definition and disorganization of the extracellular matrix. These mice also showed a decrease of CD4+CD8+ thymocytes and a higher percentage of CD4+CD8+ lymphocytes in the peripheral blood. After 7 days, the thymus and peripheral lymphocytes subsets returned to normal values. Interestingly, when the two conditions, HH condition and the infection, were associated, the mice showed a decrease in the percentage of CD4+CD8- blood lymphocytes that are involved in the modulation of immune response and have direct cytotoxic effects on the fungus. Taken together, our results showed that both conditions transitorily changed the thymus, but only when both these conditions are present do they trigger persistent changes that might be responsible for the higher susceptibility to dermatophytosis seen in HH patients.en
dc.description.affiliationUNESP Univ Estadual Paulista, Lab Imunopatol Expt, Fac Ciencias, Dept Ciencias Biol, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Med Botucatu, Botucatu, SP, Brazil
dc.description.affiliationUNIFESP Univ Fed São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Lab Imunopatol Expt, Fac Ciencias, Dept Ciencias Biol, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Med Botucatu, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent32-40
dc.identifierhttp://dx.doi.org/10.1111/j.1574-695X.2011.00784.x
dc.identifier.citationFems Immunology and Medical Microbiology. Malden: Wiley-blackwell, v. 62, n. 1, p. 32-40, 2011.
dc.identifier.doi10.1111/j.1574-695X.2011.00784.x
dc.identifier.issn0928-8244
dc.identifier.urihttp://hdl.handle.net/11449/8227
dc.identifier.wosWOS:000289832700004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofFEMS Immunology and Medical Microbiology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectexperimental diabetesen
dc.subjectdermatophytosisen
dc.subjectthymusen
dc.subjectalloxanen
dc.subjectT lymphocytes subsetsen
dc.titleMorphofunctional evaluation of thymus in hyperglycemic-hypoinsulinemic mice during dermatophytic infectionen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.orcid0000-0001-8899-4182[3]
unesp.author.orcid0000-0003-0035-2439[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentCiências Biológicas - FCpt

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