A administração precoce de hormônio de crescimento resulta em efeitos deletérios na remodelação ventricular após o infarto agudo do miocárdio

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dc.contributor.authorMill, José G.
dc.contributor.authorZornoff, Leonardo A. M.
dc.contributor.authorOkoshi, Marina P.
dc.contributor.authorOkoshi, Katashi
dc.contributor.authorPadovani, Carlos R.
dc.contributor.authorSugisaki, Mário
dc.contributor.authorLeite, Cláudia M.
dc.contributor.authorCicogna, Antônio C.
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:16Z
dc.date.available2014-05-27T11:21:16Z
dc.date.issued2005-02-01
dc.description.abstractObjective: To assess the effect of growth hormone (GH) on myocardial remodeling in infarcted rats. Methods: This study comprised 24 Wistar rats divided into 3 groups as follows: 1) AMI-GH group - comprising 8 rats that underwent infarction and were treated with GH; 2) AMI group - comprising 8 rats that underwent infarction and received only the diluent of the GH solution; and 3) control group (C group) - comprising 8 rats that underwent simulated infarction. After 30 days, the animals underwent functional study through echocardiography, and the changes in myocardial contractility of the isolated left ventricular (LV) papillary muscle were studied. Results: The echocardiography identified an increase in the diastolic (C=7.32±0.49; AMI=8.50±0.73; AMI-GH=9.34±0.73; P<0.05) and systolic (C=3.38±0.47, AMI=5.16±1.24; AMI-GH=5.96±1.54; P<0.05) diameters (mm) in the LV of the infarcted animals. The AMI-GH group animals had a lower ejection fraction (%) (C=0.9±0.03; AMI=0.76±0.12; AMI-GH=0.72± 0.14; P<0.05 for C vs AMI-GH) compared with those in controls. The study of the isolated left ventricular papillary muscle showed that the AMI-GH group had changes (C=1.50±0.59; AMI= 1.28±0.38; AMI-GH=1.98±0.41; P<0.05 for C vs AMI-GH) only in the tension at rest (TR - g/mm2) and in the time delta for a 50% decrease in the tension developed (TR50, ms) after stimulation with calcium (C=23.75±9.16; AMI=-16.56±14.82; AMI-GH=-4.69±8.39; P<0.05 for C vs AMI-GH) and in the delta of tension developed (TD, g/mm2) after stimulation with isoproterenol (C=0.99±0.17; AMI=0.54±0.62; AMI-GH=0.08±0.75; P<0.05 for C vs AMI-GH) compared with those in control animals. Conclusion: The early administration of GH in the experimental infarction model in rats may result in adverse effects on the process of ventricular remodeling.en
dc.description.affiliationUniversidade Federal de Vitoria Faculdade de Medicina, Botucatu
dc.description.affiliationFM - Clinica Medica - s/n, Cep 8618-000 Botucatu - SP
dc.format.extent115-121
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2005000200005
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 84, n. 2, p. 115-121, 2005.
dc.identifier.doi10.1590/S0066-782X2005000200005
dc.identifier.file2-s2.0-15244353911.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes1590971576309420
dc.identifier.orcid0000-0001-8980-8839
dc.identifier.scieloS0066-782X2005000200005
dc.identifier.scopus2-s2.0-15244353911
dc.identifier.urihttp://hdl.handle.net/11449/68127
dc.language.isopor
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEchocardiography
dc.subjectHypertrophy
dc.subjectPapillary muscle
dc.subjectVentricular function
dc.subjectcalcium
dc.subjectgrowth hormone
dc.subjectisoprenaline
dc.subjectacute heart infarction
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectdiastole
dc.subjectdrug effect
dc.subjectdrug utilization
dc.subjectechocardiography
dc.subjectheart left ventricle ejection fraction
dc.subjectheart left ventricle muscle
dc.subjectheart muscle contractility
dc.subjectheart muscle tension
dc.subjectheart papillary muscle
dc.subjectheart ventricle remodeling
dc.subjecthormone action
dc.subjectmale
dc.subjectmuscle excitation
dc.subjectnonhuman
dc.subjectrat
dc.subjectrat strain
dc.subjectsystole
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectGrowth Hormone
dc.subjectMale
dc.subjectMyocardial Infarction
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectVentricular Function, Left
dc.subjectVentricular Remodeling
dc.titleA administração precoce de hormônio de crescimento resulta em efeitos deletérios na remodelação ventricular após o infarto agudo do miocárdiopt
dc.title.alternativeThe early administration of growth hormone results in deleterious effects on ventricular remodeling after acute myocardial infarctionen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abc/paboutj.htm#03
unesp.author.lattes1590971576309420
unesp.author.lattes9418970103564137[8]
unesp.author.lattes8727897080522289[5]
unesp.author.orcid0000-0001-8980-8839
unesp.author.orcid0000-0002-4402-6523[8]
unesp.author.orcid0000-0002-7719-9682[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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