Metabolic syndrome reduces bone mineral density in overweight adolescents

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dc.contributor.authorSilva, Valeria Nobrega da [UNESP]
dc.contributor.authorGoldberg, Tamara Beres Lederer [UNESP]
dc.contributor.authorMosca, Luciana Nunes [UNESP]
dc.contributor.authorRizzo, Anapaula da Conceição Bisi [UNESP]
dc.contributor.authorTeixeira, Altamir dos Santos [UNESP]
dc.contributor.authorCorrente, José Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:53:21Z
dc.date.available2015-03-18T15:53:21Z
dc.date.issued2014-09-01
dc.description.abstractGrowing concern has focused on the occurrence of metabolic syndrome (MetS) and its effects on bone mass. There is little information available in the literature concerning the relationship between MetS and BMD in adolescents. The aim of this study was to evaluate the effects of MetS and its components on bone mineral density (BMD) in overweight adolescent boys and girls. This cross-sectional study assessed 271 overweight adolescents with or without MetS (age 10 to 16 years). Anthropometric and biochemical tests were performed. Lumbar spine, proximal femur and total and subtotal body BMD values were obtained by bone densitometry with dual-energy X-ray absorptiometry. MetS was observed in 14% of the adolescents. Overweight adolescents of both genders who were positive for MetS presented with significant decreases in BMD (g/cm(2)/kg bodyweight) at all sites evaluated (p < 0.01). Female adolescents with large waist circumference, low HDLc, hypertriglyceridemia and high blood pressure showed significant reductions in BMD at all sites evaluated (p < 0.01) and, with the exception of increased triglycerides (which had no effect on BMD, p> 0.05), the same pattern was observed in male adolescents. Linear regression analyses revealed that waist circumference was negatively correlated with BMD in both genders and that triglycerides were negatively correlated with BMD only in female adolescents. Our results suggest that overweight adolescents with MetS have lower BMD than adolescents without MetS. Among all MetS components measured, increased waist circumference had the strongest relationship with reductions in BMD. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationSao Paulo State Univ, UNESP, Postgrad Program Gynecol Obstet & Mastol,Dept Ped, Discipline Adolescent Med,Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ, UNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ, UNESP, Inst Biosci, Dept Stat, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Postgrad Program Gynecol Obstet & Mastol,Dept Ped, Discipline Adolescent Med,Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Inst Biosci, Dept Stat, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPro-Rector for Research of UNESP
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 07/07731-0
dc.description.sponsorshipIdFAPESP: 11/05991-0
dc.format.extent1-7
dc.identifierhttp://dx.doi.org/10.1016/j.bone.2014.05.011
dc.identifier.citationBone. New York: Elsevier Science Inc, v. 66, p. 1-7, 2014.
dc.identifier.doi10.1016/j.bone.2014.05.011
dc.identifier.issn8756-3282
dc.identifier.lattes7214834859260397
dc.identifier.orcid0000-0001-7017-766X
dc.identifier.orcid0000-0001-5478-4996
dc.identifier.urihttp://hdl.handle.net/11449/116457
dc.identifier.wosWOS:000340023800001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBone
dc.relation.ispartofjcr4.455
dc.relation.ispartofsjr1,652
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMetabolic syndrome Xen
dc.subjectAbdominal obesityen
dc.subjectWaist circumferenceen
dc.subjectBone mineral densityen
dc.subjectHypertriglyceridemiaen
dc.subjectAdolescentsen
dc.titleMetabolic syndrome reduces bone mineral density in overweight adolescentsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7214834859260397
unesp.author.lattes4025442186634278[5]
unesp.author.orcid0000-0001-7017-766X[2]
unesp.author.orcid0000-0001-5478-4996[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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