Understanding the influence of oxidative stress and physical exercise in the relationship between blood pressure and uric acid

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dc.contributor.authorJacomini, André Mourão
dc.contributor.authorZago, Anderson Saranz [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-03-02T13:03:27Z
dc.date.available2016-03-02T13:03:27Z
dc.date.issued2014
dc.description.abstractDue to the high incidence and prevalence of hypertension, especially in the elderly population, several studies have been developed to understand the relationship between etiological factors and blood pressure control. It has been demonstrated that hypertensive patients tend to present a status of hyperuricemia. This result suggested that there is a relationship between blood pressure and uric acid concentrations. However there is still a lack of studies that focus on this relationship, and especially how physical exercise could affect the relationship between both of them. Thus, the purpose of this study is to review and discuss the relationship between hypertension and uric acid concentration pointing the oxidative stress as the main factor of this relationship and discuss the physical exercise as the main preventive factor of high uric acid concentrations and oxidative stress. It has been described an increase in oxidative stress during the uric acid pathway because the high production of anions superoxide. This in turn, increases the activation of renin-angiotensin system and decreases nitric oxide bioavailability which will compromise the vasodilatation mechanism. However physical exercises have been associated with improvements in antioxidant capacity and nitric oxide production and bioavailability which will improve the blood pressure control.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Educação Física, Faculdade de Ciências de Bauru, Bauru, Av Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, CEP 17033360, SP, Brasil
dc.description.affiliationFaculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Educação Física, Faculdade de Ciências de Bauru, Bauru, Av Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, CEP 17033360, SP, Brasil
dc.format.extent221-227
dc.identifierhttp://www.ghrnet.org/index.php/jct/article/view/943
dc.identifier.citationJournal of Cardiology and Therapy, v. 1, n. 9, p. 221-227, 2014.
dc.identifier.issn2312-122X
dc.identifier.lattes2980528637146416
dc.identifier.urihttp://hdl.handle.net/11449/135589
dc.language.isoeng
dc.relation.ispartofJournal of Cardiology and Therapy
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectBlood pressureen
dc.subjectUric aciden
dc.subjectOxidative stressen
dc.subjectPhysical exerciseen
dc.titleUnderstanding the influence of oxidative stress and physical exercise in the relationship between blood pressure and uric aciden
dc.typeArtigo
unesp.author.lattes2980528637146416[2]
unesp.author.orcid0000-0002-0081-0797[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentEducação Física - FCpt

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