Gene Expression Profiles Stratified according to Type 1 Diabetes Mellitus Susceptibility Regions

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dc.contributor.authorRassi, Diane Meyre
dc.contributor.authorJunta, Cristina Moraes
dc.contributor.authorFachin, Ana Lucia
dc.contributor.authorSandrin-Garcia, Paula
dc.contributor.authorMello, Stephano
dc.contributor.authorSilva, Guilherme Liberato
dc.contributor.authorEvangelista, Adriane Feijo
dc.contributor.authorMagalhaes, Danielle Aparecida
dc.contributor.authorWastowski, Isabela Jube
dc.contributor.authorCrispim, Janaina Oliveira
dc.contributor.authorMartelli-Palomino, Gustavo
dc.contributor.authorMores Fernandes, Ana Paula
dc.contributor.authorDeghaide, Neife N. H. S.
dc.contributor.authorFoss-Freitas, Maria Cristina
dc.contributor.authorFoss, Milton Cesar
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.authorSakamoto-Hojo, Elza Tieme
dc.contributor.authorSilva Passos, Geraldo Aleixo
dc.contributor.authorDonadi, Eduardo Antonio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:01Z
dc.date.available2014-05-20T13:24:01Z
dc.date.issued2008-01-01
dc.description.abstractThe MHC region (6p21) aggregates the major genes that contribute to susceptibility to type 1 diabetes (T1D). Three additional relevant susceptibility regions mapped on chromosomes 1p13 (PTPN22), 2q33 (CTLA-4), and 11p15 (insulin) have also been described by linkage studies. To evaluate the contribution of these susceptibility regions and the chromosomes that house these regions, we performed a large-scale differential gene expression on lymphomononuclear cells of recently diagnosed T1D patients, pinpointing relevant modulated genes clustered in these regions and their respective chromosomes. A total of 4608 cDNAs from the IMAGE library were spotted onto glass slides using robotic technology. Statistical analysis was carried out using the SAM program, and data regarding gene location and biological function were obtained at the SOURCE, NCBI, and FATIGO programs. Three induced genes were observed spanning around the MHC region (6p21-6p23), and seven modulated genes (5 repressed and 2 repressed) were seen spanning around the 6q21-24 region. Additional modulated genes were observed in and around the 1p13, 2q33, and 11p15 regions. Overall, modulated genes in these regions were primarily associated with cellular metabolism, transcription factors and signaling transduction. The differential gene expression characterization may identify new genes potentially involved with diabetes pathogenesis.en
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Div Clin Med, Mol Immunogenet Grp, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Program Immunol, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Nursing Ribeirao Preto, Dept Gen & Specialized Nursing, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Div Clin Immunol, BR-14049900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo State UNESP, Sch Pharmaceut Sci, Dept Clin Anal, São Paulo, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Sch Pharmaceut Sci, Dept Clin Anal, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 150320/2007-8
dc.format.extent282-289
dc.identifierhttp://dx.doi.org/10.1196/annals.1447.064
dc.identifier.citationImmunology of Diabetes V: From Bench To Bedside. Oxford: Blackwell Publishing, v. 1150, p. 282-289, 2008.
dc.identifier.doi10.1196/annals.1447.064
dc.identifier.issn0077-8923
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/7367
dc.identifier.wosWOS:000262400400054
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofImmunology of Diabetes V: From Bench To Bedside
dc.relation.ispartofjcr4.277
dc.relation.ispartofsjr2,108
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecttype 1 diabetesen
dc.subjectsusceptibility regionsen
dc.subjectHLAen
dc.subjectgene expression profileen
dc.titleGene Expression Profiles Stratified according to Type 1 Diabetes Mellitus Susceptibility Regionsen
dc.typeArtigo
dcterms.licensehttp://www.nyas.org/Publications/Annals/AuthorGuidelines.aspx
dcterms.rightsHolderBlackwell Publishing
unesp.author.lattes1768025290373669[16]
unesp.author.orcid0000-0003-1740-7360[16]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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