Influence of Osteopenia in Autogenous Bone Graft Healing With or Without Expanded Polytetrafluoroethylene Membranes: Histologic and Histomorphometric Study in Rats

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dc.contributor.authorNascimento, Rodrigo Dias [UNESP]
dc.contributor.authorCardoso, Paula Elaine [UNESP]
dc.contributor.authorDe Marco, Andrea C.
dc.contributor.authorPugliesi Alves de Lima, Luiz Antonio
dc.contributor.authorJardini, Maria Aparecida Neves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Ibirapuera (UNIB)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:04:52Z
dc.date.available2014-05-20T14:04:52Z
dc.date.issued2009-11-01
dc.description.abstractPurpose: The aim of this study was to quantitatively evaluate and qualitatively describe autogenous bone graft healing with or without an expanded polytetrafluoroethylene (e-PTFE) membrane in ovariectornized rats. Materials and Methods: Eighty Wistar rats, weighing approximately 300 g each, were used. A graft was obtained from the parietal bone and fixed to the sidewall of each animal's left mandibular ramus. The animals were randomly divided into four experimental groups (n = 20 in each group): group 1, sham operated and autogenous bone graft only- group 2, sham operated and autogenous bone graft covered by e-PTFE membrane; group 3, ovariectornized (OVX) and autogenous bone graft only- group 4, OVX and autogenous bone graft covered by e-PTFE membrane. The animals were sacrificed at five different time points: immediately after grafting or at 7, 21, 45, or 60 days after grafting. Histologic examination and morphometric measurement of the sections were performed, and values were submitted to statistical analyses. Results: Both groups (sham and OVX) experienced loss of the original graft volume when it was not covered by the membrane, whereas use of the membrane resulted in additional bone formation beyond the edges of the graft and under the membrane. Histologic analysis showed integration of the grafts in all animals, although a larger number of marrow spaces was found in OVX groups. Conclusions: Association of bone graft with an e-PTFE membrane resulted in maintenance of its original volume as well as formation of new bone that filled the space under the membrane. Osteopenia did not influence bone graft repair, regardless of whether or not it was associated with e-PTFE membrane, but descriptive histologic analysis showed larger numbers of marrow spaces in the bone graft and receptor bed and formation of new bone in the OVX animals. INT J ORAL MAXILLOFAC IMPLANTS 2009;24:1074-1082en
dc.description.affiliationSão Paulo State Univ, Dept Diag & Surg, UNESP Sao Jose Campos, Sch Dent, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Restorat Dent, UNESP Sao Jose Campos, Sch Dent, São Paulo, Brazil
dc.description.affiliationUniv Ibirapuera, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Stomatol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Diag & Surg, UNESP Sao Jose Campos, Sch Dent, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Restorat Dent, UNESP Sao Jose Campos, Sch Dent, São Paulo, Brazil
dc.description.sponsorshipFundaq o para o Desenvolvimento da LINESP (FLINDUNESP)
dc.description.sponsorshipIdFUNDUNESP: 00219/05-DFP
dc.format.extent1074-1082
dc.identifierhttp://www.quintpub.com/journals/omi/abstract.php?article_id=6860#.Ui9l98bks_Y
dc.identifier.citationInternational Journal of Oral & Maxillofacial Implants. Hanover Park: Quintessence Publishing Co Inc, v. 24, n. 6, p. 1074-1082, 2009.
dc.identifier.issn0882-2786
dc.identifier.lattes5733639342016958
dc.identifier.lattes3570915740711695
dc.identifier.orcid0000-0003-4542-2234
dc.identifier.urihttp://hdl.handle.net/11449/22743
dc.identifier.wosWOS:000273295800012
dc.language.isoeng
dc.publisherQuintessence Publishing Co Inc
dc.relation.ispartofInternational Journal of Oral & Maxillofacial Implants
dc.relation.ispartofjcr1.699
dc.relation.ispartofsjr1,576
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbone regenerationen
dc.subjectbone transplantationen
dc.subjectmetabolic bone diseasesen
dc.titleInfluence of Osteopenia in Autogenous Bone Graft Healing With or Without Expanded Polytetrafluoroethylene Membranes: Histologic and Histomorphometric Study in Ratsen
dc.typeArtigo
dcterms.licensehttp://www.quintpub.com/journals/jop/orderreprints.php
dcterms.rightsHolderQuintessence Publishing Co Inc
unesp.author.lattes5733639342016958
unesp.author.lattes8069912321732258[3]
unesp.author.lattes3570915740711695[1]
unesp.author.orcid0000-0002-1894-7855[3]
unesp.author.orcid0000-0003-4542-2234[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Diagnóstico e Cirurgia - ICT
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