Reappraisal of immunohistochemical profiling of special histological types of breast carcinomas: a study of 121 cases of eight different subtypes

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dc.contributor.authorAlvarenga, Cesar Augusto
dc.contributor.authorParavidino, Paula Itagyba
dc.contributor.authorAlvarenga, Marcelo
dc.contributor.authorGomes, Madalena
dc.contributor.authorDufloth, Rozany [UNESP]
dc.contributor.authorZeferino, Luiz Carlos
dc.contributor.authorVassallo, Jose
dc.contributor.authorSchmitt, Fernando C.
dc.contributor.institutionUniv Porto
dc.contributor.institutionInst Patol Campinas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionFundação Antonio Prudente
dc.date.accessioned2014-05-20T15:32:00Z
dc.date.available2014-05-20T15:32:00Z
dc.date.issued2012-12-01
dc.description.abstractHistological special types (HST) account for about 25% of breast cancers, and correspond to at least 17 pathological entities. However, their molecular characteristics remain to be determined. The purpose of the present study is to apply the recently used immunohistochemical profiling of HST breast carcinomas (BC), as a surrogate for the molecular subtyping, what could be relevant for therapeutic purposes. One hundred and twenty-one cases were included. Immunohistochemical study was performed on paraffin sections, including markers for oestrogen, progesterone and androgen receptors, keratin 5, HER2/neu, epithelial growth factor receptor, p63 protein, P-cadherin, and Ki-67. Tubular (16 cases), mucinous (27) and papillary (9) types were all categorised as luminal-like A and B. The medullary (21) and metaplastic (10) types corresponded largely to the basal-like tumours (85.7% and 90%, respectively). Cases of the micropapillary type (8) were luminal A (3/8), luminal B (4/8) and HER2 overexpressing (1/8), whereas the apocrine carcinomas (24) presented a heterogeneous profile. The proliferation rate (Ki-67) varied among the types, being the medullary carcinoma subtype with higher proliferation. Comparing the current data with those based on molecular studies, there was good agreement in the classification of the tubular, mucinous and papillary types. Only a partial concordance was achieved for the other types, which may be due to sampling, and to the relatively low frequency of such cases. The present work supports the clinical usage of immunohistochemistry as a surrogate to molecular classification of special types of BC.en
dc.description.affiliationUniv Porto, IPATIMUP Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal
dc.description.affiliationInst Patol Campinas, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Dept Gynecol & Obstet, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Sch Med, Lab Invest & Mol Pathol, São Paulo, Brazil
dc.description.affiliationFundação Antonio Prudente, Hosp Canc AC Camargo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniv Porto, Fac Med, Dept Pathol & Oncol, P-4200465 Oporto, Portugal
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Pathol, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)
dc.description.sponsorshipIdFAPESP: 10/00815-6
dc.description.sponsorshipIdCAPES: 3420-09-04
dc.description.sponsorshipIdFCT, Portugal: PIC/IC/83264/2007
dc.format.extent1066-1071
dc.identifierhttp://dx.doi.org/10.1136/jclinpath-2012-200885
dc.identifier.citationJournal of Clinical Pathology. London: Bmj Publishing Group, v. 65, n. 12, p. 1066-1071, 2012.
dc.identifier.doi10.1136/jclinpath-2012-200885
dc.identifier.issn0021-9746
dc.identifier.urihttp://hdl.handle.net/11449/41005
dc.identifier.wosWOS:000311277700003
dc.language.isoeng
dc.publisherB M J Publishing Group
dc.relation.ispartofJournal of Clinical Pathology
dc.relation.ispartofjcr2.894
dc.relation.ispartofsjr1,050
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleReappraisal of immunohistochemical profiling of special histological types of breast carcinomas: a study of 121 cases of eight different subtypesen
dc.typeArtigo
dcterms.licensehttp://www.bmj.com/about-bmj/resources-authors
dcterms.rightsHolderBmj Publishing Group
unesp.author.orcid0000-0003-1006-6946[8]
unesp.author.orcid0000-0002-2192-4865[7]
unesp.author.orcid0000-0002-3711-8681[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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