Functional effects of castration on alpha(1)-adrenoceptors in rat vas deferens

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dc.contributor.authorPupo, A. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:48:59Z
dc.date.available2014-05-20T13:48:59Z
dc.date.issued1998-06-19
dc.description.abstractThe effects of castration on alpha(1)-adrenoceptors in rat vas deferens were investigated by determining the actions of selective antagonists against the contractions induced by noradrenaline. The results obtained in vas deferens from control rats suggest participation of alpha(1A)-adrenoceptors as judged by the pA(2) values for prazosin (9.6), benoxathian (9.5), 2(2,6-dimethoxyphenoxyethyl) amino-methyl-1,4-benzodioxone hydrochloride) (WB 4101) (9.6), phentolamine (8.4), 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5] decane-7,9-dionedihydrochloride (BMY 7378) (6.7) and by the insensitivity to chloroethylclonidine (100 mu M, 45 min). In vas deferens from castrated rats, WE 4101 and spiperone showed slopes lower than 1.0 in the Schild plots, suggesting participation of multiple receptors. In these organs, noradrenaline contractions were partially inhibited by chloroethylclonidine (100 mu M, 45 min), indicating participation of alpha(1B)-adrenoceptors. After chloroethylclonidine treatment, WE 4101 showed a slope not different from 1.0 in the Schild plot, resulting in a pA(2) of 9.4, which indicates an interaction with alpha(1A)-adrenoceptors. It is suggested that castration modifies the functional alpha(1)-adrenoceptors subtypes in rat vas deferens. (C) 1998 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUNESP, Inst Biociencias, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent217-223
dc.identifierhttp://dx.doi.org/10.1016/S0014-2999(98)00315-X
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 351, n. 2, p. 217-223, 1998.
dc.identifier.doi10.1016/S0014-2999(98)00315-X
dc.identifier.issn0014-2999
dc.identifier.lattes2224433126054725
dc.identifier.urihttp://hdl.handle.net/11449/17435
dc.identifier.wosWOS:000074702000009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectvas deferenspt
dc.subjectalpha(1)-adrenoceptorpt
dc.subjectcastrationpt
dc.titleFunctional effects of castration on alpha(1)-adrenoceptors in rat vas deferensen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2224433126054725[1]
unesp.author.orcid0000-0001-6627-3448[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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