Burkitt's lymphoma in Brazil: Strong association with Epstein-Barr virus

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dc.contributor.authorBacchi, M. M.
dc.contributor.authorBacchi, C. E.
dc.contributor.authorAlvarenga, M.
dc.contributor.authorMiranda, R.
dc.contributor.authorChen, Y. Y.
dc.contributor.authorWeiss, L. M.
dc.contributor.institutionCITY HOPE NATL MED CTR
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionRHODE ISL HOSP
dc.date.accessioned2014-05-20T15:20:14Z
dc.date.available2014-05-20T15:20:14Z
dc.date.issued1996-01-01
dc.description.abstractThe incidence of Burkitt's lymphoma (BL) in Brazil is intermediate between the endemic form of equatorial Africa and the sporadic form in the United States, To characterize these lymphomas, we evaluated the clinical, morphologic, and immunohistochemical features of 24 Brazilian cases of BL, We also analyzed the cases for the presence of Epstein-Barr virus (EBV)-RNA using a highly sensitive and specific method of in situ hybridization, Most cases presented with involvement of intraabdominal organs, similar to the sporadic form of BL, EBV-RNA was detected in 17 of 24 cases (71%) in all or virtually all the tumor cells, This prevalence of EBV-positivity in our cases is intermediate between the endemic form of BL in equatorial Africa (100%) and the sporadic form in the United States (30%), These findings suggest that EBV plays an important role in the pathogenesis of BL in Brazil, This intermediate incidence of EBV infection may explain in part the differences of incidence of BL in different geographic regions.en
dc.description.affiliationCITY HOPE NATL MED CTR,DIV PATHOL,DUARTE,CA 91010
dc.description.affiliationSTATE UNIV SAO PAULO,BOTUCATU,SP,BRAZIL
dc.description.affiliationUNIV CAMPINAS,CAMPINAS,SP,BRAZIL
dc.description.affiliationRHODE ISL HOSP,PROVIDENCE,RI 02902
dc.description.affiliationUnespSTATE UNIV SAO PAULO,BOTUCATU,SP,BRAZIL
dc.format.extent63-67
dc.identifier.citationModern Pathology. Baltimore: Williams & Wilkins, v. 9, n. 1, p. 63-67, 1996.
dc.identifier.issn0893-3952
dc.identifier.urihttp://hdl.handle.net/11449/31565
dc.identifier.wosWOS:A1996TT42100012
dc.language.isoeng
dc.publisherWilliams & Wilkins
dc.relation.ispartofModern Pathology
dc.relation.ispartofjcr6.655
dc.relation.ispartofsjr3,054
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBrazilpt
dc.subjectBurkitt's lymphomapt
dc.subjectEpstein-Barr viruspt
dc.subjectin situ hybridizationpt
dc.titleBurkitt's lymphoma in Brazil: Strong association with Epstein-Barr virusen
dc.typeArtigo
dcterms.licensehttp://www.nature.com/authors/policies/license.html
dcterms.rightsHolderWilliams & Wilkins
unesp.author.orcid0000-0002-8467-5464[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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