Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties

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dc.contributor.authorde Souza Silva, Flávio Kunert [UNESP]
dc.contributor.authorCosta-Orlandi, Caroline Barcelos [UNESP]
dc.contributor.authorFernandes, Mariza Aires [UNESP]
dc.contributor.authorPegorin Brasil, Giovana Sant'Ana [UNESP]
dc.contributor.authorMussagy, Cassamo Ussemane
dc.contributor.authorScontri, Mateus [UNESP]
dc.contributor.authorSasaki, Josana Carla da Silva [UNESP]
dc.contributor.authorde Sousa Abreu, Ana Paula [UNESP]
dc.contributor.authorGuerra, Nayrim Brizuela [UNESP]
dc.contributor.authorFloriano, Juliana Ferreira [UNESP]
dc.contributor.authorde Mendonça, Ricardo José
dc.contributor.authorCaetano, Guilherme Ferreira
dc.contributor.authorFarhadi, Neda
dc.contributor.authorGómez, Alejandro
dc.contributor.authorHuang, Shuyi
dc.contributor.authorFarias, Andressa Machado [UNESP]
dc.contributor.authorPrimo, Fernando Lucas [UNESP]
dc.contributor.authorLi, Bingbing
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.authorDokmeci, Mehmet Remzi
dc.contributor.authorJucaud, Vadim
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorCardoso, Marcos Roberto
dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPontificia Universidad Católica de Valparaíso
dc.contributor.institutionImperial College London
dc.contributor.institutionFederal University of Triangulo Mineiro (UFTM)
dc.contributor.institutionUniversity Center of Hermínio Ometto Foundation (FHO)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionTerasaki Institute for Biomedical Innovation (TIBI)
dc.contributor.institutionCalifornia State University
dc.date.accessioned2023-07-29T13:54:22Z
dc.date.available2023-07-29T13:54:22Z
dc.date.issued2023-07-01
dc.description.abstractNatural rubber latex (NRL) is a biopolymer widely used in biomedical applications. In this work, we propose an innovative cosmetic face mask, combining the NRL's biological properties with curcumin (CURC), which has a high level of antioxidant activity (AA) to provide anti-aging benefits. Chemical, mechanical and morphological characterizations were performed. The CURC released by the NRL was evaluated by permeation in Franz cells. Cytotoxicity and hemolytic activity assays were performed to assess safety. The findings showed that the biological properties of CURC were preserved after loading in the NRL. About 44.2 % of CURC was released within the first six hours, and in vitro permeation showed that 9.36 % ± 0.65 was permeated over 24 h. CURC–NRL was associated with a metabolic activity higher than 70 % in 3 T3 fibroblasts, cell viability ≥95 % in human dermal fibroblasts, and a hemolytic rate ≤ 2.24 % after 24 h. Furthermore, CURC-NRL maintained the mechanical characteristics (range suitable) for human skin application. We observed that CURC-NRL preserved ~20 % antioxidant activity from curcumin-free after loading in the NRL. Our results suggest that CURC–NRL has the potential to be used in the cosmetics industry, and the experimental methodology utilized in this study can be applied to different kinds of face masks.en
dc.description.affiliationBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São Paulo
dc.description.affiliationDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São Paulo
dc.description.affiliationBionanomaterials and Bioengineering Group Department of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) Faculty of Pharmaceutical Sciences, São Paulo
dc.description.affiliationEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso
dc.description.affiliationScience Faculty São Paulo State University (UNESP), São Paulo
dc.description.affiliationSão Paulo State University (UNESP) Botucatu Medical School, São Paulo
dc.description.affiliationNational Heart and Lung Institute Imperial College London
dc.description.affiliationDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), Minas Gerais
dc.description.affiliationUniversity Center of Hermínio Ometto Foundation (FHO), São Paulo
dc.description.affiliationDivision of Dermatology Department of Internal Medicine São Paulo University (USP) Ribeirão Preto Medical School, SP
dc.description.affiliationTerasaki Institute for Biomedical Innovation (TIBI), 11507 West Olympic Blvd
dc.description.affiliationAutonomy Research Center for STEAHM (ARCS) California State University
dc.description.affiliationSão Paulo State University (UNESP) School of Sciences and Languages of Assis Department of Biotechnology, São Paulo
dc.description.affiliationSão Carlos Institute of Physics University of São Paulo, PO Box 369, SP
dc.description.affiliationUnespBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São Paulo
dc.description.affiliationUnespDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São Paulo
dc.description.affiliationUnespBionanomaterials and Bioengineering Group Department of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) Faculty of Pharmaceutical Sciences, São Paulo
dc.description.affiliationUnespScience Faculty São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) Botucatu Medical School, São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Sciences and Languages of Assis Department of Biotechnology, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2017/19603-8
dc.description.sponsorshipIdFAPESP: 2018/07342-8
dc.description.sponsorshipIdFAPESP: 2021/09207-3
dc.description.sponsorshipIdCNPq: 317203/2021-5
dc.description.sponsorshipIdCNPq: 401285/2022-7
dc.description.sponsorshipIdCNPq: 470261/2012-9
dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2023.124778
dc.identifier.citationInternational Journal of Biological Macromolecules, v. 242.
dc.identifier.doi10.1016/j.ijbiomac.2023.124778
dc.identifier.issn1879-0003
dc.identifier.issn0141-8130
dc.identifier.scopus2-s2.0-85159071052
dc.identifier.urihttp://hdl.handle.net/11449/248812
dc.language.isoeng
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.sourceScopus
dc.subjectCurcumin
dc.subjectFacial mask
dc.subjectNatural rubber latex
dc.titleBiocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant propertiesen
dc.typeArtigo

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