Magnesium supplementation alleviates premenstrual symptoms of fluid retention

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dc.contributor.authorWalker, A. F.
dc.contributor.authorDe Souza, M. C.
dc.contributor.authorVickers, M. F.
dc.contributor.authorAbeyasekera, S.
dc.contributor.authorCollins, M. L.
dc.contributor.authorTrinca, L. A.
dc.contributor.institutionUniv Reading
dc.contributor.institutionRoyal Berkshire Hosp
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:51Z
dc.date.available2014-05-20T15:22:51Z
dc.date.issued1998-11-01
dc.description.abstractWe investigated the effect of a daily supplement of 200 mg of magnesium (as MgO) for two menstrual cycles on the severity of premenstrual symptoms in a randomized, double-blind, placebo-controlled, crossover study. A daily supplement of 200 mg of Mg (as MgO) or placebo was administered for two menstrual cycles to each volunteer, who kept a daily record of her symptoms, using a 4-point scale in a menstrual diary of 22 items. Symptoms were grouped into six categories: PMS-A (anxiety), PMS-C (craving), PMS-D (depression), PMS-H (hydration), PMS-O (other), and PMS-T (total overall symptoms). Urinary Mg output/24 hours was estimated from spot samples using the Mg/creatinine ratio. Analysis of variance for 38 women showed no effect of Mg supplementation compared with placebo in any category in the first month of supplementation. In the second month there was a greater reduction (p = 0.009) of symptoms of PMS-H (weight gain, swelling of extremities, breast tenderness, abdominal bloating) with Mg supplementation compared with placebo. Compliance to supplementation was confirmed by the greater mean estimated 24-hour urinary output of Mg (p = 0.013) during Mg supplementation (100.8 mg) compared with placebo (74.1 mg). A daily supplement of 200 mg of Mg (as MgO) reduced mild premenstrual symptoms of fluid retention in the second cycle of administration.en
dc.description.affiliationUniv Reading, Dept Food Sci & Technol, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England
dc.description.affiliationRoyal Berkshire Hosp, Dept Clin Biochem, Reading RG1 5AN, Berks, England
dc.description.affiliationUniv Reading, Dept Appl Stat, Reading RG6 2AH, Berks, England
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Bioestatist, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Bioestatist, São Paulo, Brazil
dc.format.extent1157-1165
dc.identifierhttp://dx.doi.org/10.1089/jwh.1998.7.1157
dc.identifier.citationJournal of Womens Health. Larchmont: Mary Ann Liebert Inc. Publ, v. 7, n. 9, p. 1157-1165, 1998.
dc.identifier.doi10.1089/jwh.1998.7.1157
dc.identifier.fileWOS000077514800020.pdf
dc.identifier.issn1059-7115
dc.identifier.lattes3720489366427955
dc.identifier.urihttp://hdl.handle.net/11449/33763
dc.identifier.wosWOS:000077514800020
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.ispartofJournal of Womens Health
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleMagnesium supplementation alleviates premenstrual symptoms of fluid retentionen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/nv/resources-tools/self-archiving-policy/51/
dcterms.rightsHolderMary Ann Liebert Inc. Publ
unesp.author.lattes3720489366427955
unesp.author.orcid0000-0003-1106-8505[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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