Alcohol use disorders in patients with obsessive-compulsive disorder: The importance of appropriate dual-diagnosis

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dc.contributor.authorGentil, Andre F.
dc.contributor.authorde Mathis, Maria Alice
dc.contributor.authorTorresan, Ricardo C. [UNESP]
dc.contributor.authorDiniz, Juliana B.
dc.contributor.authorAlvarengat, Pedro
dc.contributor.authordo Rosario, Maria Conceicao
dc.contributor.authorCordioli, Aristides V.
dc.contributor.authorTorres, Albina Rodrigues [UNESP]
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.date.accessioned2014-05-20T13:36:10Z
dc.date.available2014-05-20T13:36:10Z
dc.date.issued2009-02-01
dc.description.abstractObjective: To evaluate the prevalence and clinical associated factors of alcohol use disorders (AUD) comorbidity in a large clinical sample of patients with obsessive-compulsive disorder (OCD).Methods: A cross-sectional study including 630 DSM-IV OCD patients from seven Brazilian university services, comparing patients with and without AUD comorbidity. The instruments of assessment used were a demographic and clinical questionnaire including evaluation of suicidal thoughts and acts and psychiatric treatment, the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I), the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Brown Assessment of Beliefs Scale, the Beck Depression and Anxiety Inventories and the Clinical Global Impression Scale. Current or past alcohol and other psychoactive substances use, abuse and dependence were assessed using the SCID-I (section E) and corroborated by medical and familial history questionnaires.Results: Forty-seven patients (7.5%) presented AUD comorbidity. Compared to OCD patients without this comorbidity they were more likely to be men, to have received previous psychiatric treatment, to present: lifetime suicidal thoughts and attempts and to have higher scores in the hoarding dimension. They also presented higher comorbidity with generalized anxiety and somatization disorders, and compulsive sexual behavior. Substance use was related to the appearance of the first O.C. symptoms and symptom amelioration.Conclusions: Although uncommon among OCD treatment seeking samples, AUD comorbidity has specific clinical features, such as increased risk for suicidality, which deserve special attention from mental health professionals. Future studies focused on the development of specific interventions for these patients are warranted. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med, Clin Hosp, Dept & Inst Psychiat, BR-05403010 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed São Paulo, Sch Med, Dept Psychiat, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Sch Med, Dept Psychiat, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 521369/96-7
dc.description.sponsorshipIdCNPq: 475919/2006-8
dc.description.sponsorshipIdFAPESP: 05/55628-08
dc.description.sponsorshipIdFAPESP: 06/50273-0
dc.format.extent173-177
dc.identifierhttp://dx.doi.org/10.1016/j.drugalcdep.2008.09.010
dc.identifier.citationDrug and Alcohol Dependence. Clare: Elsevier B.V., v. 100, n. 1-2, p. 173-177, 2009.
dc.identifier.doi10.1016/j.drugalcdep.2008.09.010
dc.identifier.issn0376-8716
dc.identifier.lattes3837157956819433
dc.identifier.urihttp://hdl.handle.net/11449/12462
dc.identifier.wosWOS:000262756900024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofDrug and Alcohol Dependence
dc.relation.ispartofjcr3.322
dc.relation.ispartofsjr1,715
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectObsessive-compulsive disorderen
dc.subjectAlcohol use disordersen
dc.subjectAlcohol abuseen
dc.subjectAlcohol dependenceen
dc.subjectComorbidityen
dc.subjectClinical sampleen
dc.titleAlcohol use disorders in patients with obsessive-compulsive disorder: The importance of appropriate dual-diagnosisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3837157956819433[8]
unesp.author.orcid0000-0001-9486-3779[4]
unesp.author.orcid0000-0002-9687-0072[6]
unesp.author.orcid0000-0003-1072-5008[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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