Effect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy men

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dc.contributor.authorCastro, AVB
dc.contributor.authorMendonca, B. B.
dc.contributor.authorBloise, W.
dc.contributor.authorShuhama, T.
dc.contributor.authorBrandaoNeto, J.
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:23:55Z
dc.date.available2014-05-20T15:23:55Z
dc.date.issued1999-12-01
dc.description.abstractPrevious in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner. Thus, Zn++ may regulate physiologically pituitary PRL secretion. Furthermore, studies with patients with uremia, cirrhosis or prolactinoma, have shown the coexistence of hypozincemia and hyperprolactinemia and zinc supplementation did not correct hyperprolactinemia in these patients. In normal individuals Zn++ administration produced controversial results on PRL secretion. Here, we investigated whether zinc administration affects TRH-stimulated PRL in healthy men. We found that Zn++ administration does not change the TRH-stimulated PRL. Therefore, in normal conditions, Zn++ does not inhibit TRH-stimulated prolactinemia. In addition, we found that acute increases of blood PRL and TRH do not alter blood Zn++ levels.en
dc.description.affiliationUnB, Fac Ciências Saude, Unidade Endocrinol & Metab, Brasilia, DF, Brazil
dc.description.affiliationUSP, Fac Ciências Farmaceut, Lab Quim Analit, Ribeirao Preto, SP, Brazil
dc.description.affiliationUSP, Fac Med, Unidade Endocrinol, BR-09500900 São Paulo, Brazil
dc.description.affiliationUNESP, Fac Med, Unidade Endocrinol & Metab, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Med, Unidade Endocrinol & Metab, São Paulo, Brazil
dc.format.extent347-352
dc.identifierhttp://dx.doi.org/10.1023/A:1009225904221
dc.identifier.citationBiometals. Dordrecht: Kluwer Academic Publ, v. 12, n. 4, p. 347-352, 1999.
dc.identifier.doi10.1023/A:1009225904221
dc.identifier.issn0966-0844
dc.identifier.urihttp://hdl.handle.net/11449/34605
dc.identifier.wosWOS:000085277700009
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofBiometals
dc.relation.ispartofjcr2.478
dc.relation.ispartofsjr0,744
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectzinc tolerance testpt
dc.subjectthyrotropin tolerance testpt
dc.subjectprolactin secretionpt
dc.subjecthealthy menpt
dc.titleEffect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy menen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic Publ

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