Evaluation of Preservative Effectiveness of Liquid Crystalline Systems with Retynil Palmitate by the Challenge Test and D-value

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dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorLeonardi, Gislaine Ricci
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.authorScarpa, Maria Virginia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Metodista Piracicaba
dc.date.accessioned2014-05-20T13:24:55Z
dc.date.available2014-05-20T13:24:55Z
dc.date.issued2011-01-01
dc.description.abstractThe objective of this work was to evaluate the preservative effectiveness of liquid crystalline systems containing retynil palmitate (RP) by the challenge test (CT) and D-value. A system was developed containing water, silicon glycol copolymer, and polyether functional siloxane with 1% RP added. The analyses were carried out by methods in the U.S. Pharmacopeia (USP 31, 2008) using the microorganisms Escherichia coil, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger. The CT showed that after 7 days, all microorganisms were eliminated except A. niger, which maintained viability for at least 28 days after inoculation. Moreover, the microorganisms E. coil, P. aeruginosa, S. aureus, C. albicans, and A. niger presented different growth behaviors, evidenced by differences among the D-values calculated. It was concluded that the CT and D-value were efficient methods for evaluation of the preservative property of these formulations.en
dc.description.affiliationUNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Metodista Piracicaba, BR-13400760 Piracicaba, SP, Brazil
dc.description.affiliationUnespUNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.format.extent118-127
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21391488
dc.identifier.citationJournal of Aoac International. Gaithersburg: Aoac Int, v. 94, n. 1, p. 118-127, 2011.
dc.identifier.issn1060-3271
dc.identifier.urihttp://hdl.handle.net/11449/7859
dc.identifier.wosWOS:000287222000015
dc.language.isoeng
dc.publisherAoac Int
dc.relation.ispartofJournal of AOAC International
dc.relation.ispartofjcr1.087
dc.relation.ispartofsjr0,324
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleEvaluation of Preservative Effectiveness of Liquid Crystalline Systems with Retynil Palmitate by the Challenge Test and D-valueen
dc.typeArtigo
dcterms.licensehttp://mc.manuscriptcentral.com/societyimages/aoac_jaoac/copyright.pdf
dcterms.rightsHolderAoac Int
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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