Bacteria-derived hydrogen sulfide promotes IL-8 production from epithelial cells

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dc.contributor.authorChen, Weilin
dc.contributor.authorKajiya, Mikihito
dc.contributor.authorGiro, Gabriela [UNESP]
dc.contributor.authorOuhara, Kazuhisa
dc.contributor.authorMackler, Harrison E.
dc.contributor.authorMawardi, Hani
dc.contributor.authorBoisvert, Heike
dc.contributor.authorDuncan, Margaret J.
dc.contributor.authorSato, Kimihiro
dc.contributor.authorKawai, Toshihisa
dc.contributor.institutionForsyth Inst
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSkyview Enterprises
dc.date.accessioned2013-09-30T18:31:53Z
dc.date.accessioned2014-05-20T13:45:26Z
dc.date.available2013-09-30T18:31:53Z
dc.date.available2014-05-20T13:45:26Z
dc.date.issued2010-01-01
dc.description.abstractHydrogen Sulfide (H(2)S) a volatile Sulfur compound, is implicated as a cause of inflammation. especially when it is produced by bacteria colonizing gastrointestinal organs However, It IS Unclear if H(2)S produced by periodontal pathogens affects the inflammatory responses mediated by oral/gingival epithelial cells Therefore. the aims of this Study were (1) to compare the in vitro production of H(2)S among. 14 strains of Oral bacteria and (2) to evaluate the effects of H(2)S on inflammatory response induced in host oral/gingival epithelial cells Porphyromonas gingivalis (Pg) produced the most H(2)S in Culture, Which, in turn resulted in the promotion of proinflammatory cytokine IL-8 from both gingival and Oral epithelial cells The up-regulation of IL-8 expression was reproduced by the exogenously applied H(2)S Furthermore. the Mutant Strains of Pg that do not produce major Soluble Virulent factors. ie gingival, still showed the Production of H(2)S. as well as the promotion of epithelial IL-8 production. which was abrogated by H(2)S scavenging reagents These results demonstrated that Pg produces a concentration of H(2)S capable of Up-regulating-IL-8 expression induced in gingival and oral epithelial cells, revealing a possible mechanism that may promote the inflammation in periodontal disease (C) 2009 Elsevier B.V. All rights reserveden
dc.description.affiliationForsyth Inst, Dept Immunol, Boston, MA 02115 USA
dc.description.affiliationForsyth Inst, Dept Mol Genet, Boston, MA 02115 USA
dc.description.affiliationUNESP, Dept Oral Diag & Surg, Sch Dent Araraquara, Jaboticabal, SP, Brazil
dc.description.affiliationSkyview Enterprises, New York, NY USA
dc.description.affiliationUnespUNESP, Dept Oral Diag & Surg, Sch Dent Araraquara, Jaboticabal, SP, Brazil
dc.description.sponsorshipSkyview Enterprises
dc.description.sponsorshipNIH
dc.description.sponsorshipHoward Hughes Medical Institute
dc.description.sponsorshipIdNIH: DE-018310
dc.description.sponsorshipIdNIH: DE-015931
dc.format.extent645-650
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2009.11.113
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 391, n. 1, p. 645-650, 2010.
dc.identifier.doi10.1016/j.bbrc.2009.11.113
dc.identifier.issn0006-291X
dc.identifier.urihttp://hdl.handle.net/11449/15986
dc.identifier.wosWOS:000273624500113
dc.language.isoeng
dc.publisherAcademic Press Inc. Elsevier B.V.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.ispartofjcr2.559
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHydrogen sulfideen
dc.subjectEpithelial cellsen
dc.subjectIL-8en
dc.subjectBacteriaen
dc.subjectPorphyromonas gingivalisen
dc.subjectGingipainen
dc.subjectPathogenesisen
dc.subjectHydrogenen
dc.subjectInnate immune responseen
dc.subjectPeriodontal diseaseen
dc.titleBacteria-derived hydrogen sulfide promotes IL-8 production from epithelial cellsen
dc.typeTrabalho apresentado em evento
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc. Elsevier B.V.
unesp.author.orcid0000-0002-7590-8158[3]
unesp.author.orcid0000-0001-6652-0007[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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