Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

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dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorCalixto, Giovana [UNESP]
dc.contributor.authorRimerio, Thereana Cristina [UNESP]
dc.contributor.authorScarpa, Maria Virginia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:09:13Z
dc.date.available2014-12-03T13:09:13Z
dc.date.issued2013-10-03
dc.description.abstractLiposomes containing hydrogenated soy phosphatidylcholine (PCH), with or without cholesterol (CHOL) and caffeine (CAF), were prepared by sonication and characterized for encapsulation efficiency and mean diameter. Dynamic light scattering assay showed that the incorporation of CHOL decreased significantly the size of the liposomes and led to a more heterogeneous distribution of size raising the CAF encapsulation efficiency. The in vitro drug release studies showed that the encapsulation of the CAF in liposomes produced a reduction in the release rate and the inclusion of CHOL in the liposome formulation delayed still further the release of the CAF.en
dc.description.affiliationSao Paulo State Univ, UNESP, Sch Pharmaceut Sci, BR-14801902 Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Sch Pharmaceut Sci, BR-14801902 Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1465-1470
dc.identifierhttp://dx.doi.org/10.1080/01932691.2012.739535
dc.identifier.citationJournal Of Dispersion Science And Technology. Philadelphia: Taylor & Francis Inc, v. 34, n. 10, p. 1465-1470, 2013.
dc.identifier.doi10.1080/01932691.2012.739535
dc.identifier.issn0193-2691
dc.identifier.lattes1427125996716282
dc.identifier.urihttp://hdl.handle.net/11449/112075
dc.identifier.wosWOS:000324904800021
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Dispersion Science and Technology
dc.relation.ispartofjcr1.454
dc.relation.ispartofsjr0,375
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCaffeineen
dc.subjecthydrogenated soy phosphatidylcholineen
dc.subjectin vitro drug releaseen
dc.subjectliposomesen
dc.titleCaffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profileen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes1427125996716282
unesp.author.orcid0000-0002-6698-0545[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR