Serum Vitamins in Adult Patients With Short Bowel Syndrome Receiving Intermittent Parenteral Nutrition

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dc.contributor.authorMoreno Braga, Camila Bitu
dc.contributor.authorVannucchi, Helio
dc.contributor.authorMurbach Freire, Cristiana Maria [UNESP]
dc.contributor.authorMarchini, Julio Sergio
dc.contributor.authorJordao Junior, Alceu Afonso
dc.contributor.authorde Carvalho da Cunha, Selma Freire
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:24Z
dc.date.available2014-05-20T15:32:24Z
dc.date.issued2011-07-01
dc.description.abstractBackground: Short bowel syndrome (SBS) occurs after massive intestinal resection, and parenteral nutrition (PN) therapy may be necessary even after a period of adaptation. The purpose of this study was to determine the vitamin status in adults with SBS receiving intermittent PN. Methods: The study was conducted on hospitalized adults with SBS who were receiving intermittent PN therapy (n = 8). Nine healthy volunteers, paired by age and sex, served as controls. Food ingestion, anthropometry, plasma folic acid, and vitamins B-12, C, A, D, E, and K were evaluated. Results: The levels of vitamins A, D, and B-12 in both groups were similar. SBS patients presented higher values of folic acid (21.3 +/- 4.4 vs 14.4 +/- 5.2, P = .01) and lower values of vitamin C (0.9 +/- 0.4 vs 1.2 +/- 0.3 mg/dL, P = .03), alpha-tocopherol (16.3 +/- 3.4 vs 24.1 +/-+/- 2.7 mu mol/L, P < .001), and phylloquinone (0.6 +/- 0.2 vs 1.0 +/- 0.5 nmol/L, P < .03). Eight-seven percent of patients had vitamin D deficiency, and all patients presented with serum vitamin E levels below reference values. Conclusions: Despite all efforts to offer all the nutrients mentioned above, SBS patients had lower serum levels of vitamins C, E, and K, similar to those observed in patients on home PN. These findings suggest that the administered vitamins were not sufficient for the intermittent PN scheme and that individual adjustments are needed depending on the patient's vitamin status. (JPEN J Parenter Enteral Nutr. 2011;35:493-498)en
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Internal Med, Ribeirao Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ Julio de Mesquita Filho, Fac Med Botucatu, Expt Lab Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ Julio de Mesquita Filho, Fac Med Botucatu, Expt Lab Internal Med, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/52058-1
dc.format.extent493-498
dc.identifierhttp://dx.doi.org/10.1177/0148607110386964
dc.identifier.citationJournal of Parenteral and Enteral Nutrition. Thousand Oaks: Sage Publications Inc, v. 35, n. 4, p. 493-498, 2011.
dc.identifier.doi10.1177/0148607110386964
dc.identifier.issn0148-6071
dc.identifier.urihttp://hdl.handle.net/11449/41319
dc.identifier.wosWOS:000292051800015
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Parenteral and Enteral Nutrition
dc.relation.ispartofjcr4.249
dc.relation.ispartofsjr1,580
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectnutrition evaluationen
dc.subjectadultsen
dc.subjectparenteral nutritionen
dc.subjectshort bowel syndromeen
dc.subjectserum vitaminsen
dc.titleSerum Vitamins in Adult Patients With Short Bowel Syndrome Receiving Intermittent Parenteral Nutritionen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Inc
unesp.author.orcid0000-0001-9999-9149[4]
unesp.author.orcid0000-0003-4161-3228[2]
unesp.author.orcid0000-0002-4092-4502[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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