Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy

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dc.contributor.authorPontes-Cardoso, Lizandra Carla Rigoletti [UNESP]
dc.contributor.authorSouza, L. R. [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorPereira, Paulo Câmara Marques [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:30Z
dc.date.available2014-05-27T11:22:30Z
dc.date.issued2007-06-29
dc.description.abstractThe extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-α, IFN-γ, IL-2, IL-10, and TNF-α type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy group and zidovudine with the non-lipodystrophy group. CD4 and CD8 values, viral load, glucose, albumin, and lipids were not different between groups, except for triglycerides, which were high in the lipodystrophy group, and HDL, whose concentration was reduced in G1. TNF-α, TNF-RII, and IL-10 profiles were high and had positive correlation; IL-2 and IFN-γ had reduced levels in the lipodystrophy group. High TNF-α and its receptor levels seem to be associated with lipodystrophy development in individuals under HAART therapy.en
dc.description.affiliationDepartment of Tropical Diseases Botucatu School of Medicine São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartamento de Doenças Tropicais Faculdade de Medicina de Botucatu UNESP, 18618-000, Botucatu, SP
dc.description.affiliationUnespDepartment of Tropical Diseases Botucatu School of Medicine São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, UNESP, Botucatu, São Paulo State
dc.description.affiliationUnespDepartamento de Doenças Tropicais Faculdade de Medicina de Botucatu UNESP, 18618-000, Botucatu, SP
dc.format.extent509-526
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992007000200009
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 2, p. 509-526, 2007.
dc.identifier.doi10.1590/S1678-91992007000200009
dc.identifier.file2-s2.0-34250802570.pdf
dc.identifier.issn1678-9199
dc.identifier.lattes1365320427418204
dc.identifier.lattes6486557387397806
dc.identifier.orcid0000-0001-5771-8943
dc.identifier.scieloS1678-91992007000200009
dc.identifier.scopus2-s2.0-34250802570
dc.identifier.urihttp://hdl.handle.net/11449/69725
dc.identifier.wosWOS:000249389300009
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCytokines
dc.subjectHIV-1
dc.subjectHypertriglyceridemia
dc.subjectLipodystrophy
dc.subjectHuman immunodeficiency virus
dc.subjectHuman immunodeficiency virus 1
dc.titleCytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophyen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
unesp.advisor.lattes6486557387397806
unesp.author.lattes1365320427418204[4]
unesp.author.orcid0000-0001-5771-8943[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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