Catecholaminergic responses in vas deferens isolated from rats submitted to acute swimming stress

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dc.contributor.authorChies, A. B.
dc.contributor.authorPereira, OCM
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:53Z
dc.date.available2014-05-20T15:27:53Z
dc.date.issued1995-09-01
dc.description.abstractThe study was performed to examine the responses to catecholamines in vas deferens isolated from rats submitted to acute swimming-induced stress. It was demonstrated that acute stress induces a significant subsensitivity of rat vas deferens to norepinephrine. This subsensitivity was inhibited when the experiment was carried out in the presence of either cocaine (10(-5) M) or timolol (10(-5) M). on the other hand, the rat vas deferens sensitivity to methoxamine was significantly increased by acute swimming-induced stress. Thus, despite acute swimming stress inducing a reduction in response to norepinephrine, the alpha(1)-adrenoceptor-mediated contractile response was increased. Additionally there were increases in neuronal uptake and beta(2)-adrenoceptor activity that opposes the alpha(1)-adrenoceptor activity. Integrated, these phenomena are responsible for the rat vas deferens subsensitivity to norepinephrine which may be involved in body homeostasis in stressogenic situations. (C) 1995 the Italian Pharmacological Societyen
dc.description.affiliationUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT FARMACOL,BR-18618000 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,INST BIOCIENCIAS,DEPT FARMACOL,BR-18618000 BOTUCATU,SP,BRAZIL
dc.format.extent123-127
dc.identifierhttp://dx.doi.org/10.1016/S1043-6618(05)80004-0
dc.identifier.citationPharmacological Research. London: Academic Press Ltd, v. 32, n. 3, p. 123-127, 1995.
dc.identifier.doi10.1016/S1043-6618(05)80004-0
dc.identifier.issn1043-6618
dc.identifier.urihttp://hdl.handle.net/11449/37800
dc.identifier.wosWOS:A1995TT59500004
dc.language.isoeng
dc.publisherAcademic Press Ltd
dc.relation.ispartofPharmacological Research
dc.relation.ispartofjcr4.897
dc.relation.ispartofsjr1,811
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectacute stresspt
dc.subjectcatecholaminespt
dc.subjectadrenoceptorpt
dc.subjectneuronal uptakept
dc.titleCatecholaminergic responses in vas deferens isolated from rats submitted to acute swimming stressen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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