Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model

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dc.contributor.authorScolastici, C.
dc.contributor.authorOng, T. P.
dc.contributor.authorMoreno, F. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:49Z
dc.date.available2014-05-20T15:22:49Z
dc.date.issued2004-01-01
dc.description.abstractThe eventual chemopreventive effect of squalene (SQ), a triterpene present in olive oil, was evaluated when administered to Wistar rats during a period comprising the initiation and selection/promotion of the resistant hepatocyte (RH) model of hepatocarcinogenesis. During 8 consecutive wk, animals received by gavage SQ (100 or 150 mg/100 g body weight) dissolved in corn oil (CO) daily. Animals treated with only CO and submitted to the RH model were used as controls. Treatments with SQ did not result in inhibition of macroscopically visible hepatocyte nodules (P > 0.05) or of hepatic placental glutathione S-transferase-positive preneoplastic lesions (PNL; P > 0.05). Hepatic cell proliferation and apoptosis indexes were not different (P > 0.05) among the different experimental groups, both regarding PNL and surrounding normal tissue areas. There were no significant differences (P > 0.05) among comets presented by rats treated with the two SQ doses or with CO. on the other hand, SQ increased total plasma cholesterol levels when administered at both doses (P < 0.05). This indicates that the isoprenoid was absorbed. Thus, SQ did not present chemopreventive activity during hepatocarcinogenesis and had a hypercholesterolemic effect, suggesting caution when considering its use in chemoprevention of cancer.en
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, Dept Alimentos & Nutr Expt, Lab Diet Nutr & Canc, BR-05508900 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Pathol, Fac Med, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Pathol, Fac Med, São Paulo, Brazil
dc.format.extent101-109
dc.identifierhttp://dx.doi.org/10.1207/s15327914nc5001_13
dc.identifier.citationNutrition and Cancer-an International Journal. Mahwah: Lawrence Erlbaum Associação Inc., v. 50, n. 1, p. 101-109, 2004.
dc.identifier.doi10.1207/s15327914nc5001_13
dc.identifier.issn0163-5581
dc.identifier.urihttp://hdl.handle.net/11449/33728
dc.identifier.wosWOS:000225580800013
dc.language.isoeng
dc.publisherLawrence Erlbaum Associação Inc
dc.relation.ispartofNutrition and Cancer-an International Journal
dc.relation.ispartofjcr2.261
dc.relation.ispartofsjr0,745
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleSqualene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis modelen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderLawrence Erlbaum Associação Inc

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