Abnormalities in apolipoprotein and lipid levels in an HIV-infected Brazilian population under different treatment profiles: the relevance of apolipoprotein E genotypes and immunological status

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dc.contributor.authorMalavazi, I
dc.contributor.authorAbrao, E. P.
dc.contributor.authorMikawa, A. Y.
dc.contributor.authorLandgraf, V. O.
dc.contributor.authorCosta, Paulo Inácio da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:32Z
dc.date.available2014-05-20T13:24:32Z
dc.date.issued2004-01-01
dc.description.abstractHIV infection is associated with disturbances in lipid metabolism due to a host's response mechanism and the current antiretroviral therapy. The pathological appearance and progression of atherosclerosis is dependent on the presence of injurious agents in the vascular endothelium and variations in different subsets of candidate genes. Therefore, the Hha I polymorphism in the apolipoprotein E gene was evaluated in addition to triglycerides, total cholesterol, very low-density lipoprotein (VLDL), LDL, high-density lipoprotein (HDL), and apolipoprotein (apo) Al, B and E levels in 86 Brazilian HIV-infected patients and 29 healthy controls. The allele frequency for apoE in the HIV-infected group and controls was in agreement with data on the Brazilian population. Dyslipidemia was observed in the HIV group and verified by increased levels of triglycerides, VLDL and apoE, and decreased levels of HDL and apoAl. The greatest abnormalities in these biochemical variables were shown in the HIV-infected individuals whose immune function was more compromised. The effect of the genetic variation at the APOE gene on biochemical variables was more pronounced in the HIV-infected individuals who carried the apoE2/3 genotype. The highly active antiretroviral therapy (HAART)-receiving group presented increased levels of total cholesterol and apoE. Dyslipidemia was a predictable consequence of HIV infection and the protease inhibitors intensified the increase in apoE values.en
dc.description.affiliationSão Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Araraquara, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Fac Pharmaceut Sci, Inst Chem, Araraquara, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Araraquara, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Fac Pharmaceut Sci, Inst Chem, Araraquara, Brazil
dc.format.extent525-532
dc.identifierhttp://dx.doi.org/10.1515/CCLM.2004.089
dc.identifier.citationClinical Chemistry and Laboratory Medicine. Berlin: Walter de Gruyter & Co, v. 42, n. 5, p. 525-532, 2004.
dc.identifier.doi10.1515/CCLM.2004.089
dc.identifier.issn1434-6621
dc.identifier.lattes6720223715917381
dc.identifier.orcid0000-0002-3350-8308
dc.identifier.urihttp://hdl.handle.net/11449/7648
dc.identifier.wosWOS:000221760400009
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofClinical Chemistry and Laboratory Medicine
dc.relation.ispartofjcr3.556
dc.relation.ispartofsjr1,114
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectapolipoprotein E (apoE)pt
dc.subjectapoE polymorphismpt
dc.subjectCD4+lymphocytespt
dc.subjectcoronary artery diseasept
dc.subjecthighly active antiretroviral therapy (HAART)pt
dc.subjectHIVpt
dc.titleAbnormalities in apolipoprotein and lipid levels in an HIV-infected Brazilian population under different treatment profiles: the relevance of apolipoprotein E genotypes and immunological statusen
dc.typeArtigo
dcterms.licensehttp://www.degruyter.com/dg/page/576/repository-policy
dcterms.rightsHolderWalter de Gruyter & Co
unesp.author.lattes6720223715917381[5]
unesp.author.orcid0000-0002-3350-8308[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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