Influence of low-level laser therapy on wound healing in nicotine-treated animals

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dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorMacarini, Valmir Campos [UNESP]
dc.contributor.authorAlmeida, Juliano Milanezi de [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorOkamoto, Tetuo [UNESP]
dc.contributor.authorLongo, Mariellen [UNESP]
dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBarretos Dent Sch
dc.date.accessioned2013-09-30T18:29:37Z
dc.date.accessioned2014-05-20T13:43:21Z
dc.date.available2013-09-30T18:29:37Z
dc.date.available2014-05-20T13:43:21Z
dc.date.issued2012-03-01
dc.description.abstractLow-level laser therapy (LLLT) has been shown to have several biological effects that favor the healing process, and nicotine has been shown to delay the healing process. In this study we investigated the healing of open wounds created on the back of rats treated with nicotine with or without LLLT. of 115 animals, 59 received subcutaneous injections of saline solution, and the others received subcutaneous injections of nicotine (3 mg/kg body weight), twice a day throughout the study period. After 30 days, skin wounds were created on the back of the animals. The animals receiving saline injections were divided into two groups: group 1 (G1, n = 29), in which the wounds were left untreated, and group 2 (G2, n = 30), in which the wounds were treated with LLLT (GaAlAs, 660 nm, 30 mW, 5.57 J/cm(2) per point, 0.39 J, 13 s per point, 0.42 W/cm(2)). The animals receiving nicotine injections were also divided into two groups: group 3 (G3, n = 29), in which the wounds were left untreated, and group 4 (G4, n = 27), in which the wounds were treated with LLLT. The animals were killed 3, 7 or 14 days after surgery. Wound healing was evaluated histologically both qualitatively and semiquantitatively. Wounds of G2 showed a delay in epithelial migration and connective tissue organization compared to those of G1. Wounds of G2 showed faster healing than those of G1; similarly, wounds of G4 showed more advanced healing than those of G3. LLLT acted as a biostimulatory coadjuvant agent balancing the undesirable effects of nicotine on wound tissue healing.en
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Aracatuba, Disciplina Periodontia, Dept Cirurgia & Clin Integrada, BR-16015050 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Div Periodont, Dept Surg, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Div Periodont, Integrated Clin, São Paulo, Brazil
dc.description.affiliationBarretos Dent Sch, FEB Educ Fdn Barretos, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Aracatuba, Disciplina Periodontia, Dept Cirurgia & Clin Integrada, BR-16015050 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Div Periodont, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Div Periodont, Integrated Clin, São Paulo, Brazil
dc.format.extent437-443
dc.identifierhttp://dx.doi.org/10.1007/s10103-011-0956-4
dc.identifier.citationLasers In Medical Science. London: Springer London Ltd, v. 27, n. 2, p. 437-443, 2012.
dc.identifier.doi10.1007/s10103-011-0956-4
dc.identifier.issn0268-8921
dc.identifier.lattes4068921369233125
dc.identifier.lattes9831236034935598
dc.identifier.lattes8399870097572073
dc.identifier.lattes0169955363968097
dc.identifier.lattes4774447118127346
dc.identifier.urihttp://hdl.handle.net/11449/15114
dc.identifier.wosWOS:000300588500025
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofLasers in Medical Science
dc.relation.ispartofjcr1.949
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLaser/therapeutic useen
dc.subjectWound healingen
dc.subjectNicotineen
dc.subjectBiomodulationen
dc.titleInfluence of low-level laser therapy on wound healing in nicotine-treated animalsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer London Ltd
unesp.author.lattes4068921369233125
unesp.author.lattes9831236034935598
unesp.author.lattes8399870097572073
unesp.author.lattes0169955363968097
unesp.author.lattes4774447118127346
unesp.author.orcid0000-0002-6715-8334[1]
unesp.author.orcid0000-0001-5903-5652[5]
unesp.author.orcid0000-0002-5995-5747[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Cirurgia e Clínica Integrada - FOA