Comparison of caffeine-induced locomotor activity between adolescent and adult rats

Página do item simplificado
dc.contributor.authorMarin, Marcelo Tadeu [UNESP]
dc.contributor.authorZancheta, Roberta [UNESP]
dc.contributor.authorParo, Ana H. [UNESP]
dc.contributor.authorPossi, Ana P. M. [UNESP]
dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:25:36Z
dc.date.available2014-05-20T13:25:36Z
dc.date.issued2011-06-25
dc.description.abstractCaffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimulant or depressant effects in adolescent and adult rats. Adolescent (37-40 days old) or adult (70-74 days old) Wistar rats were tested for stimulant and depressant caffeine effects in two different experiments. The first was designed to evaluate the locomotor effect of caffeine in habituated rats. To this end, rats were previously habituated to test environment and had their locomotor activity registered following i.p. injections of vehicle or caffeine (3, 10, 30, 60 or 120 mg/kg). In the second experiment adolescent or adult rats were not habituated to the test environment and their locomotor activity was registered following i.p. injections of vehicle or caffeine (30, 60 or 120 mg/kg). In both experiments caffeine-induced a biphasic effect, with stimulation in small to moderate drug doses and no effect or locomotor depression in higher caffeine doses. Moreover, caffeine-induced locomotor stimulation was higher in adolescent than adult rats. Also, locomotor depression was only revealed in adult rats non-habituated to the test environment. These results suggest that adult and adolescent respond differently to caffeine indicating the need of more studies on the effects of caffeine in animals' models of adolescence. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, UNESP, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de Uberlândia (UFU), Inst Biomed Sci, BR-38400902 Uberlandia, MG, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Interinst Grad Program Physiol Sci, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, UNESP, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent363-367
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2011.03.052
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 660, n. 2-3, p. 363-367, 2011.
dc.identifier.doi10.1016/j.ejphar.2011.03.052
dc.identifier.fileWOS000291623600017.pdf
dc.identifier.issn0014-2999
dc.identifier.lattes2514762545280942
dc.identifier.lattes7920438802539727
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8131
dc.identifier.wosWOS:000291623600017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCaffeineen
dc.subjectAdolescenceen
dc.subjectLocomotor activityen
dc.subjectPsychostimulanten
dc.titleComparison of caffeine-induced locomotor activity between adolescent and adult ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7920438802539727
unesp.author.lattes2514762545280942[6]
unesp.author.orcid0000-0002-1378-6327[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000291623600017.pdf
Tamanho:
388.19 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR