Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

Página do item simplificado
dc.contributor.authorBoschiero, Clarissa [UNESP]
dc.contributor.authorJorge, Erika C.
dc.contributor.authorNinov, Kerli
dc.contributor.authorNones, Kátia
dc.contributor.authordo Rosário, Millor Fernandes
dc.contributor.authorCoutinho, Luiz Lehmann
dc.contributor.authorLedur, Mônica Corrêa
dc.contributor.authorBurt, David W.
dc.contributor.authorMoura, Ana Silvia A.M.T. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversity of Edinburgh
dc.date.accessioned2014-05-27T11:28:13Z
dc.date.available2014-05-27T11:28:13Z
dc.date.issued2013-01-25
dc.description.abstractTwo functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F2 chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c. 47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c. 34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0. 0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p < 0. 0001) with abdominal fat was observed, and also associations with body weight, feed intake, percentages of carcass, drums and thighs, gizzard and haematocrit. Our findings suggest that the KDM5A gene might play an important role in the abdominal fat deposition in chickens. The IGF1 and KDM5A genes are strong candidates to explain the QTL mapped in this region of GGA1. © 2012 Institute of Plant Genetics, Polish Academy of Sciences, Poznan.en
dc.description.affiliationDepartamento de Produção Animal Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista (UNESP), Botucatu, SP, 18618-970
dc.description.affiliationDepartamento de Zootecnia, Escola Superior de Agricultura Luiz de Queiróz (ESALQ) Universidade de São Paulo (USP), Av. Pádua Dias 11, Piracicaba, SP, 13418-900
dc.description.affiliationEmbrapa Suínos e Aves, BR 153, Km 110, Concórdia, SC, 89700-000
dc.description.affiliationDivision of Genetics and Genomics The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh, Midlothian, Edinburgh, EH25 9RG
dc.description.affiliationUnespDepartamento de Produção Animal Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista (UNESP), Botucatu, SP, 18618-970
dc.format.extent103-112
dc.identifierhttp://dx.doi.org/10.1007/s13353-012-0129-6
dc.identifier.citationJournal of Applied Genetics, v. 54, n. 1, p. 103-112, 2013.
dc.identifier.doi10.1007/s13353-012-0129-6
dc.identifier.issn1234-1983
dc.identifier.scopus2-s2.0-84872653250
dc.identifier.urihttp://hdl.handle.net/11449/74419
dc.identifier.wosWOS:000313737500013
dc.language.isoeng
dc.relation.ispartofJournal of Applied Genetics
dc.relation.ispartofjcr1.756
dc.relation.ispartofsjr0,704
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAbdominal fat
dc.subjectAdditive effect
dc.subjectBody weight
dc.subjectFeed intake
dc.subjectHaematocrit
dc.subjectSNP
dc.subjectretinoblastoma binding protein 2
dc.subjectsomatomedin C
dc.subjectabdominal fat
dc.subjectavian stomach
dc.subjectbody weight
dc.subjectcarcass
dc.subjectchicken
dc.subjectepigenetics
dc.subjectfemale
dc.subjectfood intake
dc.subjectgene frequency
dc.subjectgene mutation
dc.subjectgene sequence
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenotyping technique
dc.subjecthematocrit
dc.subjectmale
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectquantitative trait locus
dc.subjectsingle nucleotide polymorphism
dc.titleAssociation of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickensen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.orcid0000-0002-2645-4735[7]
unesp.author.orcid0000-0002-6575-5266[1]
unesp.author.orcid0000-0002-7266-8881[6]
unesp.author.orcid0000-0002-2105-7319[9]
unesp.author.orcid0000-0002-9991-1028[8]
unesp.author.orcid0000-0001-5390-5266[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

Arquivos

Coleções

Artigos - Produção Animal - FMVZ