Implication of the RDRio Mycobacterium tuberculosis sublineage in multidrug resistant tuberculosis in Portugal

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dc.contributor.authorDavid, Susana
dc.contributor.authorDuarte, Elsa L.
dc.contributor.authorFugimura Leite, Clarice Queico [UNESP]
dc.contributor.authorRibeiro, Joao-Nuno
dc.contributor.authorMaio, Jose-Nuno
dc.contributor.authorPaixao, Eleonora
dc.contributor.authorPortugal, Clara
dc.contributor.authorSancho, Luisa
dc.contributor.authorde Sousa, Jose Germano
dc.contributor.institutionInst Nacl Saúde Dr Ricardo Jorge INSA
dc.contributor.institutionUniv Evora
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIBMC
dc.contributor.institutionHosp Fernando Fonseca
dc.date.accessioned2014-05-20T15:33:16Z
dc.date.available2014-05-20T15:33:16Z
dc.date.issued2012-10-01
dc.description.abstractMultidrug and extensively drug resistant Mycobacterium tuberculosis are a threat to tuberculosis control programs. Genotyping methods, such as spoligotyping and MIRU-VNTR typing (Mycobacterial Interspersed Repetitive Units), are useful in monitoring potentially epidemic strains and estimating strain phylogenetic lineages and/or genotypic families. M. tuberculosis Latin American Mediterranean (LAM) family is a major worldwide contributor to tuberculosis (TB). LAM specific molecular markers, Ag85C(103) single nucleotide polymorphism (SNP) and RDRio long-sequence polymorphism (LSP), were used to characterize spoligotype signatures from 859 patient isolates from Portugal. LAM strains were found responsible for 57.7% of all tuberculosis cases. Strains with the RDRio deletion (referred to as RDRio) were estimated to represent 1/3 of all the strains and over 60% of the multidrug resistant (MDR) strains. The major spoligotype signature SIT20 belonging to the LAM1 RDRio sublineage, represented close to 1/5th of all the strains, over 20% of which were MDR. Analysis of published datasets according to stipulated 12 loci MIRU-VNTR RDRio signatures revealed that 96.3% (129/134) of MDR and extensively drug resistant (XDR) clusters were RDRio. This is the first report associating the LAM RDRio sublineage with MDR. These results are an important contribution to the monitoring of these strains with heightened transmission for future endeavors to arrest MDR-TB and XDR-TB. (c) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationInst Nacl Saúde Dr Ricardo Jorge INSA, IP, Oporto, Portugal
dc.description.affiliationUniv Evora, Escola Ciencias & Tecnol ICAAM, Evora, Portugal
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Araraquara, SP, Brazil
dc.description.affiliationIBMC, Grp Microbiol & Imunol Infeccao, Oporto, Portugal
dc.description.affiliationHosp Fernando Fonseca, Serv Patol Clin, Amadora, Portugal
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Araraquara, SP, Brazil
dc.description.sponsorshipLuso-American Development Foundation (LACR Award program)
dc.format.extent1362-1367
dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2012.04.021
dc.identifier.citationInfection Genetics and Evolution. Amsterdam: Elsevier B.V., v. 12, n. 7, p. 1362-1367, 2012.
dc.identifier.doi10.1016/j.meegid.2012.04.021
dc.identifier.issn1567-1348
dc.identifier.urihttp://hdl.handle.net/11449/41941
dc.identifier.wosWOS:000310114600005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInfection, Genetics and Evolution
dc.relation.ispartofjcr2.545
dc.relation.ispartofsjr1,278
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosisen
dc.subjectMultidrug resistant tuberculosis (MDR-TB)en
dc.subjectLatin American Mediterranean familyen
dc.subjectSpoligotypingen
dc.subjectRDRio sublineageen
dc.titleImplication of the RDRio Mycobacterium tuberculosis sublineage in multidrug resistant tuberculosis in Portugalen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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