A biópsia de linfonodo sentinela não deve ser recomendada para pacientes portadores de melanoma espesso

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dc.contributor.authorde Oliveira Filho, Renato Santos [UNESP]
dc.contributor.authorda Silva, Allisson Monteiro
dc.contributor.authorde Oliveira, Daniel Arcuschin
dc.contributor.authorOliveira, Gustavo Gianotto
dc.contributor.authorNahas, Fabio Xerfan
dc.contributor.institutionCenter for Cancer Prevention 'Prof. Dr. Renato Santos Clinic'
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHead and Neck Surgeon
dc.contributor.institutionMedical School Graduate
dc.contributor.institutionSão Paulo Federal University
dc.date.accessioned2014-05-27T11:28:36Z
dc.date.available2014-05-27T11:28:36Z
dc.date.issued2013-03-01
dc.description.abstractObjective: To ascertain whether there is any relationship between the state of the sentinel lymph node histopathology, recurrence and mortality from thick melanoma in patients undergoing SLNB over a long follow-up. Methods: Eighty-six patients with thick melanoma undergoing SLNB were selected from a prospective database. Lymphoscintigraphy, lymphatic mapping and intraoperative gamma probe detection were performed in all patients. The sentinel lymph node (SLN) was analyzed by HE and immunohistochemistry. Complete lymphadenectomy was indicated for patients with positive sentinel node. The histopathological SLN status was related to the rate of recurrence and mortality from melanoma. Results: One hundred and sixty-six SLNs were taken from the 86 patients. Ages ranged from 18 to 73 years. There were 47 women and 39 men. Micrometastases were found in 44 patients. Forty-two patients underwent complete lymphadenectomy. Seven other patients had positive lymph node. Among the 44 patients with positive sentinel node, there were 20 recurrences and 15 deaths. There were 18 recurrences and 12 deaths in the group with negative SLN. The Breslow thickness was not correlated with the histopathological SLN status. The histopathological SLN status did not affect the rates of recurrence and mortality (Fisher test, p = 1.00). The median follow-up was 69 months. Conclusion: Considering the lack of evidence of benefit, SLNB should not be indicated for patients with thick melanoma outside of clinical studies.en
dc.description.affiliationCenter for Cancer Prevention 'Prof. Dr. Renato Santos Clinic', S̃o Paulo - SP
dc.description.affiliationSão Paulo State University, S̃o Paulo - SP
dc.description.affiliationHead and Neck Surgeon, S̃o Paulo - SP
dc.description.affiliationMedical School Graduate, São Paulo
dc.description.affiliationSão Paulo Federal University, S̃o Paulo - SP
dc.description.affiliationUnespSão Paulo State University, S̃o Paulo - SP
dc.format.extent127-129
dc.identifierhttp://dx.doi.org/10.1590/S0100-69912013000200008
dc.identifier.citationRevista do Colegio Brasileiro de Cirurgioes, v. 40, n. 2, p. 127-129, 2013.
dc.identifier.doi10.1590/S0100-69912013000200008
dc.identifier.file2-s2.0-84878981623.pdf
dc.identifier.issn0100-6991
dc.identifier.issn1809-4546
dc.identifier.scieloS0100-69912013000200008
dc.identifier.scopus2-s2.0-84878981623
dc.identifier.urihttp://hdl.handle.net/11449/74743
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofRevista do Colégio Brasileiro de Cirurgiões
dc.relation.ispartofsjr0,221
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectMelanoma
dc.subjectMortality
dc.subjectNeoplasms micrometastasis
dc.subjectRecurrence
dc.subjectSentinel lymph node biopsy
dc.titleA biópsia de linfonodo sentinela não deve ser recomendada para pacientes portadores de melanoma espessopt
dc.title.alternativeSentinel node biopsy should not be recommended for patients with thick melanomaen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rcbc/paboutj.htm#03

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