Deuterium Equilibrium Time in Saliva of Newborn Infants

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dc.contributor.authorMarti Traver, Luis Angelo
dc.contributor.authorMartinez, Francisco Eulogio
dc.contributor.authorFerriolli, Eduardo
dc.contributor.authorMarchini, Julio Sergio
dc.contributor.authorMonteiro, Jacqueline Pontes
dc.contributor.authorPfrimer, Karina
dc.contributor.authorMichelin Sanchez, Ana Paula
dc.contributor.authorde Oliveira, Thais
dc.contributor.authorDucatti, Carlos [UNESP]
dc.contributor.authorCamelo, Jose Simon
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:37Z
dc.date.available2014-05-20T13:49:37Z
dc.date.issued2009-04-01
dc.description.abstractThere is an increasing interest about the use of stable isotopes for body composition analysis in pediatrics. To ensure the success of total body water analysis by the deuterium dilution method, it is fundamental to determine the equilibrium tune (plateau) of deuterium in the body fluid studied.Objectives: We report here the equilibration time of deuterium oxide in the saliva of newborns after oral intake of the isotope.Methods: Twenty healthy term newborn infants, 10 males and 10 females, were analyzed. Saliva was collected from each newborn before the oral administration of a 100 mg/kg dose of deuterium oxide (baseline sample) and then at 1-hour intervals for 5 hours after administration. Deuterium enrichment of saliva was determined by isotope ratio mass spectrometry according to the recommendations of the International Atomic Energy Agency.Results: The plateau time of deuterium in saliva occurred 3 hours after oral administration of the stable isotope.Conclusion: These data are essential for further studies on the body composition of newborn infants. To the best of our knowledge, this is the first study regarding the equilibration time of deuterium in the saliva of term newborns. JPGN 48:471-474, 2009.en
dc.description.affiliationUniv São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Lab Mass Spectrometry, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Nutr Course, Sch Med Ribeirao Preto, São Paulo, Brazil
dc.description.affiliationIBB UNESP, Dept Phys & Biophys, Stable Isotopes Ctr, São Paulo, Brazil
dc.description.affiliationUnespIBB UNESP, Dept Phys & Biophys, Stable Isotopes Ctr, São Paulo, Brazil
dc.description.sponsorshipInternational Atomic Energy Agency, Nestle Nutrition
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent471-474
dc.identifierhttp://journals.lww.com/jpgn/Fulltext/2009/04000/Deuterium_Equilibrium_Time_in_Saliva_of_Newborn.15.aspx#
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 48, n. 4, p. 471-474, 2009.
dc.identifier.issn0277-2116
dc.identifier.lattes1030251743943217
dc.identifier.urihttp://hdl.handle.net/11449/17695
dc.identifier.wosWOS:000264671600015
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.relation.ispartofjcr2.752
dc.relation.ispartofsjr1,376
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBody compositionen
dc.subjectDeuteriumen
dc.subjectNewbornen
dc.subjectSalivaen
dc.subjectTBWen
dc.titleDeuterium Equilibrium Time in Saliva of Newborn Infantsen
dc.typeArtigo
dcterms.licensehttp://edmgr.ovid.com/spine/accounts/copyrightTransfer.pdf
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes1030251743943217
unesp.author.orcid0000-0001-9148-4669[6]
unesp.author.orcid0000-0001-9999-9149[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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