Assessment of chemokine serum levels in epithelial ovarian cancer patients

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dc.contributor.authorAlmeida Falcao-Junior, Joao Oscar [UNESP]
dc.contributor.authorTeixeira-Carvalho, Andrea
dc.contributor.authorCandido, Eduardo Batista
dc.contributor.authorLages, Elisa Lopes [UNESP]
dc.contributor.authorGustavo Ferreira Freitas, G. [UNESP]
dc.contributor.authorLamaita, Rivia Mara
dc.contributor.authorFreire Bonfim, Livia Paula [UNESP]
dc.contributor.authorSalera, Rafael Borges [UNESP]
dc.contributor.authorTraiman, Paulo [UNESP]
dc.contributor.authorSilva-Filho, Agnaldo Lopes da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionOswaldo Cruz Fdn Belo Horizonte
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionMaterDei Hosp
dc.date.accessioned2014-12-03T13:10:34Z
dc.date.available2014-12-03T13:10:34Z
dc.date.issued2013-07-01
dc.description.abstractAims and background. The study was undertaken to investigate CCL2/MCP-1, CCL3/MIP-l alpha, CCL4/MIP-1 beta, CCL5/RANTES and CXCL8/IL-8 women with epithelial ovarian cancer.Methods and study design. Sixteen patients diagnosed with epithelial ovarian cancer and 18 healthy women with no evidence of malign neoplasia (control group) aged from 23 to 89 years (mean +/- SEM, 58.7 +/- 2.3) were included. The epithelial ovarian cancer patients underwent laparotomy and debulking surgery Chemokines serum levels were measured by cytometric bead array. Statistical analysis was performed using Mann-Whitney and Kendall's tau. P <0.05 was considered statistically significant for all analyses.Results. The tumor staging (FIGO) was classified into: I in 4 cases (25%), III in 5 cases (31.3%) and stage IV in 7 cases (43.8%). Sera chemokine dosages of CCL2 /MCP-1 and CCL4/MIP-1 beta were lower in epithelial ovarian cancer patients than in the control group (P = 0.021 and P = 0.030, respectively). No significant difference between groups was observed in the levels of CCL3/MIP-l alpha, CCL5/RANTES and CXCL8/IL-8. No association between the chemokines analyzed and tumor stage was found. The serum level of CCL4/MIP-1 beta was correlated with CA-125.Conclusions. The study of serum levels of CCL2/MCP-1, CCL3/MIP-l alpha, CCL4/MIP-1 beta, CCL5/RANTES and CXCL8/IL-8 chemokines in epithelial ovarian cancer patients identified a down-regulation in CCL2/MCP-1 and CCL4/MIP-1 beta, which suggests that the two chemokines may play an important role in the pathophysiology of ovarian cancer.en
dc.description.affiliationSao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Obstet Gynecol & Mastol, Botucatu, SP, Brazil
dc.description.affiliationOswaldo Cruz Fdn Belo Horizonte, Rene Rachou Res Ctr, Lab Biomarkers & Monitoring Diag, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Obstet & Gynecol, BR-30130100 Belo Horizonte, MG, Brazil
dc.description.affiliationMaterDei Hosp, Procriar Clin Assisted Reprod, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Obstet Gynecol & Mastol, Botucatu, SP, Brazil
dc.format.extent540-544
dc.identifierhttp://dx.doi.org/10.1700/1361.15108
dc.identifier.citationTumori. Rome: Pensiero Scientifico Editor, v. 99, n. 4, p. 540-544, 2013.
dc.identifier.issn0300-8916
dc.identifier.lattes8334785337106990
dc.identifier.urihttp://hdl.handle.net/11449/112264
dc.identifier.wosWOS:000329001000017
dc.language.isoeng
dc.publisherPensiero Scientifico Editor
dc.relation.ispartofTumori
dc.relation.ispartofjcr1.304
dc.relation.ispartofsjr0,396
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCA-125en
dc.subjectchemokinesen
dc.subjectcytometricen
dc.subjectbead arrayen
dc.subjectimmune systemen
dc.subjectovarian canceren
dc.titleAssessment of chemokine serum levels in epithelial ovarian cancer patientsen
dc.typeArtigo
dcterms.rightsHolderPensiero Scientifico Editor
unesp.author.lattes8334785337106990
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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