Perinatal Androgenic Exposure and Reproductive Health Effects Female Rat Offspring

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dc.contributor.authorGuerra, Marina T.
dc.contributor.authorSilva, Raquel F. [UNESP]
dc.contributor.authorLuchiari, Heloise R. [UNESP]
dc.contributor.authorSanabria, Marciana [UNESP]
dc.contributor.authorKempinas, Wilma De Grava [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:07:07Z
dc.date.available2014-12-03T13:07:07Z
dc.date.issued2014-04-03
dc.description.abstractEnvironmental contaminants known as endocrine-disrupting chemicals (EDC) have been associated with adverse effects on reproductive processes. These chemicals may mimic or antagonize endogenous hormones, disrupting reproductive functions. Although preliminary studies focused on environmental estrogens, the presence of compounds with androgenic activity has also been described. This study examines exposure of female pregnant and lactating rats to low doses of androgens and assesses potential effects on female offspring. Pregnant Wistar rats were exposed to testosterone propionate (TP) at doses of 0.05, 0.1, or 0.2 mg/kg or corn oil (vehicle), subcutaneously, to determine influence on reproductive health of female offspring. There were two exposure groups: (1) rats treated from gestational day (GD) 12 until GD 20; and (2) animals treated from GD 12 until the end of lactation. Perinatal exposure to TP produced increased anogenital distance after birth and diminished height of uterine glandular epithelium at puberty in animals exposed to 0.2 mg/kg. However, these alterations were not sufficient to impair sexual differentiation and normal physiology of the female rat reproductive tract.en
dc.description.affiliationState Univ Campinas UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Sao Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Sao Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipSilva RF scholarchip
dc.description.sponsorshipLuchiari HR grant
dc.description.sponsorshipIdCNPq: 501339/2010-8
dc.description.sponsorshipIdFAPESP: 09/00352-9
dc.description.sponsorshipIdCNPq: 3049058/2009-3
dc.description.sponsorshipIdFAPESP: 2010/08715-0
dc.description.sponsorshipIdCNPq: 501340/2010-6
dc.format.extent375-389
dc.identifierhttp://dx.doi.org/10.1080/15287394.2013.874881
dc.identifier.citationJournal Of Toxicology And Environmental Health-part A-current Issues. Philadelphia: Taylor & Francis Inc, v. 77, n. 7, p. 375-389, 2014.
dc.identifier.doi10.1080/15287394.2013.874881
dc.identifier.issn1528-7394
dc.identifier.lattes6326450271169741
dc.identifier.urihttp://hdl.handle.net/11449/111262
dc.identifier.wosWOS:000333986900002
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Toxicology and Environmental Health: Part A Current Issues
dc.relation.ispartofjcr2.706
dc.relation.ispartofsjr0,888
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titlePerinatal Androgenic Exposure and Reproductive Health Effects Female Rat Offspringen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes6326450271169741
unesp.author.orcid0000-0002-1637-6075[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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