Fine-tuning of a nanostructure, swelling, and drug delivery profile by blending ureasil-PEO and ureasil-PPO hybrids

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dc.contributor.authorMolina, Eduardo F. [UNESP]
dc.contributor.authorPulcinelli, Sandra Helena [UNESP]
dc.contributor.authorBriois, Valerie
dc.contributor.authorSantilli, Celso Valentim [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSynchrotron SOLEIL
dc.date.accessioned2014-12-03T13:08:38Z
dc.date.available2014-12-03T13:08:38Z
dc.date.issued2014-01-01
dc.description.abstractUrea-cross-linked polyether-siloxane hybrid blends with tuneable hydrophilic/hydrophobic features were prepared from a mixture of poly(ethylene oxide) (PEO1900) and poly(propylene oxide) (PPO2000), hybridized by end-chain functionalization with (3-isocyanatopropyl)triethoxysilane. The aim of this study was to demonstrate that combination of different polymer phases produces materials with hydrophilic and hydrophobic domains. Swellability and the drug release profile could be easily tuned by varying the ureasil-PEO/ureasil-PPO ratio in the hybrid matrix. Differential scanning calorimetry (DSC) and small-angle X-ray scattering (SAXS) analyses indicated that the nanostructure of the hybrid blends could be described by the existence of a homogeneous mixture of PEO1900 and PPO2000 in the hybrid network, with a fraction of lamellar domains being derived from the PEO1900 crystallinity. A correlation between the nanoscopic features and the kinetics of the swelling mechanism is proposed, based on the results of in situ SAXS analyses. In situ UV-vis spectroscopy monitoring indicated that the kinetics of drug release from the PEO1900-PPO2000 hybrid blends could be controlled by varying the proportions of the hydrophilic (PEO) and hydrophobic (PPO) molecules.en
dc.description.affiliationUNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationSynchrotron SOLEIL, F-91192 Gif Sur Yvette, France
dc.description.affiliationUnespUNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFrench agency COFECUB
dc.description.sponsorshipLNLS (Brazil)
dc.description.sponsorshipIdFrench agency COFECUBPh 564/07
dc.format.extent1897-1904
dc.identifierhttp://dx.doi.org/10.1039/c3py01126g
dc.identifier.citationPolymer Chemistry. Cambridge: Royal Soc Chemistry, v. 5, n. 6, p. 1897-1904, 2014.
dc.identifier.doi10.1039/c3py01126g
dc.identifier.issn1759-9954
dc.identifier.lattes9971202585286967
dc.identifier.lattes5584298681870865
dc.identifier.orcid0000-0002-8356-8093
dc.identifier.urihttp://hdl.handle.net/11449/111416
dc.identifier.wosWOS:000332477100012
dc.language.isoeng
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofPolymer Chemistry
dc.relation.ispartofjcr4.927
dc.relation.ispartofsjr1,778
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleFine-tuning of a nanostructure, swelling, and drug delivery profile by blending ureasil-PEO and ureasil-PPO hybridsen
dc.typeArtigo
dcterms.rightsHolderRoyal Soc Chemistry
unesp.author.lattes9971202585286967
unesp.author.lattes5584298681870865[4]
unesp.author.orcid0000-0002-8356-8093[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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