Immunostimulatory and cytotoxic activities of Indigofera suffruticosa (Fabaceae)

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dc.contributor.authorLopes, Flavia C. M. [UNESP]
dc.contributor.authorCalvo, Tamara Regina [UNESP]
dc.contributor.authorColombo, Lucas L.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Buenos Aires
dc.date.accessioned2014-05-20T13:23:59Z
dc.date.available2014-05-20T13:23:59Z
dc.date.issued2011-01-01
dc.description.abstractOne of the major disadvantages of the current cancer therapy is the suppression of the immune system. Brazilian flora is considered one of the most diverse in the world and many plants were found to contain active constituents that can be valuable sources of new drugs. The plant Indigofera suffruticosa was studied to determine its potential to stimulate the immune system and also to be effective against tumour cells. We investigated the effects of the alkaloidal fraction and the pure alkaloid indigo obtained from I. suffruticosa on macrophage activation by measuring nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production. Cytotoxic activity was also evaluated against the two tumour murine cells lines, LM2 (breast adenocarcinoma) and LP07 (lung adenocarcinoma). The alkaloidal fraction induced a high NO production and a moderated TNF-alpha release. The pure indigo demonstrated an elevated NO and TNF-alpha production. The fraction and the pure compound also exhibited cytotoxic activity against both adenocarcinoma cell lines and indigo showed the strongest cytotoxic activity with IC50 value of 0.89 mu g mL(-1) against LM2 and 1.44 mu g mL(-1) against LP07. Our results presented the immunostimulatory and cytotoxic activity of I. suffruticosa, enhancing macrophage function and therefore contributing to the host defence against tumours.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Clin Anal, Fac Ciencias Farmaceut, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Organ Chem, Inst Quim, Botucatu, SP, Brazil
dc.description.affiliationUniv Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Clin Anal, Fac Ciencias Farmaceut, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Organ Chem, Inst Quim, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 02/05503-6
dc.format.extent1796-1806
dc.identifierhttp://dx.doi.org/10.1080/14786419.2010.488624
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 25, n. 19, p. 1796-1806, 2011.
dc.identifier.doi10.1080/14786419.2010.488624
dc.identifier.issn1478-6419
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7347
dc.identifier.wosWOS:000299692600003
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.relation.ispartofjcr1.928
dc.relation.ispartofsjr0,671
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalkaloidal fractionen
dc.subjectindigoen
dc.subjectnitric oxideen
dc.subjecttumour necrosis factor-alphaen
dc.subjecttumour cell linesen
dc.titleImmunostimulatory and cytotoxic activities of Indigofera suffruticosa (Fabaceae)en
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
unesp.author.orcid0000-0003-3032-2556[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Química Orgânica - IQ