Stromal cell interplay in prostate development, physiology, and pathological conditions

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dc.contributor.authorSanches, Bruno D. A.
dc.contributor.authorMaldarine, Juliana S.
dc.contributor.authorVilamaior, Patricia S. L. [UNESP]
dc.contributor.authorFelisbino, Sergio L. [UNESP]
dc.contributor.authorCarvalho, Hernandes F.
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:30:38Z
dc.date.available2022-04-29T08:30:38Z
dc.date.issued2021-09-01
dc.description.abstractAdvances in prostatic stroma studies over the past few decades have demonstrated that the stroma not only supports and nourishes the gland's secretory epithelium but also participates in key aspects of morphogenesis, in the prostate's hormonal metabolism, and in the functionality of the secretory epithelium. Furthermore, the stroma is implicated in the onset and progression of prostate cancer through the formation of the so-called reactive stroma, which corresponds to a tumorigenesis-permissive microenvironment. Prostatic stromal cells are interconnected and exchange paracrine signals among themselves in a gland that is highly sensitive to endocrine hormones. There is a growing body of evidence that telocytes, recently detected interstitial cells that are also present in the prostate, are involved in stromal organization, so that their processes form a network of interconnections with both the epithelium and the other stromal cells. The present review provides an update on the different types of prostate stromal cells, their interrelationships and implications for prostate development, physiology and pathological conditions.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Biological Sciences Laboratory of Microscopy and Microanalysis São Paulo State University—UNESP
dc.description.affiliationInstitute of Biosciences São Paulo State University—UNESP
dc.description.affiliationUnespDepartment of Biological Sciences Laboratory of Microscopy and Microanalysis São Paulo State University—UNESP
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University—UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 302938/2020-6
dc.format.extent926-937
dc.identifierhttp://dx.doi.org/10.1002/pros.24196
dc.identifier.citationProstate, v. 81, n. 13, p. 926-937, 2021.
dc.identifier.doi10.1002/pros.24196
dc.identifier.issn1097-0045
dc.identifier.issn0270-4137
dc.identifier.scopus2-s2.0-85109768785
dc.identifier.urihttp://hdl.handle.net/11449/229127
dc.language.isoeng
dc.relation.ispartofProstate
dc.sourceScopus
dc.subjectcastration
dc.subjectCD34
dc.subjecthormonal metabolism
dc.subjectparacrine signaling
dc.subjectreactive stroma
dc.subjectsenescence
dc.subjectsmooth muscle cells
dc.subjectstem cells
dc.subjecttelocytes
dc.subjecttissue organization
dc.titleStromal cell interplay in prostate development, physiology, and pathological conditionsen
dc.typeResenha
unesp.author.orcid0000-0001-9559-5497[3]
unesp.author.orcid0000-0002-6870-5192[4]
unesp.author.orcid0000-0002-3080-9447[5]
unesp.author.orcid0000-0002-0970-4288[6]

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Botucatu - CME - Centro de Microscopia Eletrônica