PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)

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dc.contributor.authorSmith, E. M.D.
dc.contributor.authorAggarwal, A.
dc.contributor.authorAinsworth, J.
dc.contributor.authorAl-Abadi, E.
dc.contributor.authorAvcin, T.
dc.contributor.authorBortey, L.
dc.contributor.authorBurnham, J.
dc.contributor.authorCiurtin, C.
dc.contributor.authorHedrich, C. M.
dc.contributor.authorKamphuis, S.
dc.contributor.authorLambert, L.
dc.contributor.authorLevy, D. M.
dc.contributor.authorLewandowski, L.
dc.contributor.authorMaxwell, N.
dc.contributor.authorMorand, E.
dc.contributor.authorOzen, S.
dc.contributor.authorPain, C. E.
dc.contributor.authorRavelli, A.
dc.contributor.authorSaad Magalhaes, C. [UNESP]
dc.contributor.authorPilkington, C.
dc.contributor.authorSchonenberg-Meinema, D.
dc.contributor.authorScott, C.
dc.contributor.authorTullus, K.
dc.contributor.authorBeresford, M. W.
dc.contributor.authorGoilav, B.
dc.contributor.authorMarks, S.
dc.contributor.authorOni, L.
dc.contributor.institutionUniversity of Liverpool
dc.contributor.institutionAlder Hey Children's NHS Foundation Trust
dc.contributor.institutionSanjay Gandhi Postgraduate Institute of Medical Sciences
dc.contributor.institutionBirmingham Women's and Children's Hospital NHS Foundation Trust
dc.contributor.institutionUniversity Medical Center Ljubljana
dc.contributor.institutionChildren's Hospital of Philadelphia
dc.contributor.institutionUniversity College London
dc.contributor.institutionErasmus University Medical Center
dc.contributor.institutionThe Hospital for Sick Children and University of Toronto
dc.contributor.institutionNational Institutes of Health
dc.contributor.institutionMonash University
dc.contributor.institutionHacettepe University
dc.contributor.institutionIRCCS Istituto Giannina Gaslini
dc.contributor.institutionUniversità degli Studi di Genova
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionGreat Ormond Street Hospital for Children NHS Foundation Trust
dc.contributor.institutionUniversity of Amsterdam
dc.contributor.institutionUniversity of Cape Town
dc.contributor.institutionAlbert Einstein College of Medicine
dc.contributor.institutionGreat Ormond Street Hospital for Children NHS Foundation Trust and the NIHR Great Ormond Street Hospital Biomedical Research Centre
dc.date.accessioned2023-07-29T13:48:24Z
dc.date.available2023-07-29T13:48:24Z
dc.date.issued2023-05-01
dc.description.abstractObjective: To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials. Methods: The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria. Results: The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS). They agreed upon five cLLDAS criteria: (1) SLE Disease Activity Index (SLEDAI)-2 K ≤4, with no activity in major organ systems; (2) no new features of lupus disease activity compared with the last assessment; (3) Physician Global Assessment score of ≤1 (0–3 scale); (4) prednisolone dose of ≤0.15 mg/kg/day, 7.5 mg/day/maximum; while on (5) stable antimalarials, immunosuppressives, and biologics. Conclusions: A cSLE-appropriate definition of cLLDAS has been generated, maintaining alignment with the adult-SLE definition to promote life-course research.en
dc.description.affiliationDepartment of Women's & Children's Health Institute of Life Course and Medical Sciences University of Liverpool
dc.description.affiliationDepartment of Paediatric Rheumatology Alder Hey Children's NHS Foundation Trust
dc.description.affiliationDepartment of Clinical Immunology & Rheumatology Sanjay Gandhi Postgraduate Institute of Medical Sciences
dc.description.affiliationDepartment of Paediatric Rheumatology Birmingham Women's and Children's Hospital NHS Foundation Trust
dc.description.affiliationDepartment of Allergology Rheumatology and Clinical Immunology Children's Hospital University Medical Center Ljubljana
dc.description.affiliationTARGET Lupus Public Patient Involvement and Engagement Group Institute of Life Course and Medical Sciences University of Liverpool
dc.description.affiliationDepartment of Pediatric Rheumatology Children's Hospital of Philadelphia
dc.description.affiliationCentre for Adolescent Rheumatology Versus Arthritis Division of Medicine University College London
dc.description.affiliationDepartment of Pediatric Rheumatology Sophia Children's Hospital Erasmus University Medical Center
dc.description.affiliationDivision of Rheumatology Department of Pediatrics The Hospital for Sick Children and University of Toronto
dc.description.affiliationLupus Genomics and Global Health Disparities Unit Systemic Autoimmunity Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health
dc.description.affiliationCentre for Inflammatory Diseases Monash University
dc.description.affiliationDepartment of Pediatrics Hacettepe University
dc.description.affiliationDirezione Scientifica IRCCS Istituto Giannina Gaslini
dc.description.affiliationDipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno Infantili (DINOGMI) Università degli Studi di Genova
dc.description.affiliationDepartment of Pediatric Rheumatology Botucatu Medical School Sao Paulo State University
dc.description.affiliationDepartment of Paediatric Rheumatology Great Ormond Street Hospital for Children NHS Foundation Trust
dc.description.affiliationDepartment of Pediatric Immunology Rheumatology and Infectious diseases Emma Children's Hospital Amsterdam University Medical Centres University of Amsterdam
dc.description.affiliationClinical Research Centre Department of Pediatric Rheumatology University of Cape Town
dc.description.affiliationDepartment of Paediatric Nephrology Great Ormond Street Hospital for Children NHS Foundation Trust
dc.description.affiliationAlbert Einstein College of Medicine
dc.description.affiliationGreat Ormond Street Hospital for Children NHS Foundation Trust and the NIHR Great Ormond Street Hospital Biomedical Research Centre
dc.description.affiliationDepartment of Women’'s & Children’'s Health Institute of Life Course and Medical Sciences University of Liverpool
dc.description.affiliationUnespDepartment of Pediatric Rheumatology Botucatu Medical School Sao Paulo State University
dc.description.sponsorshipNational Institute of Arthritis and Musculoskeletal and Skin Diseases
dc.description.sponsorshipUniversity of Liverpool
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipVersus Arthritis
dc.identifierhttp://dx.doi.org/10.1016/j.clim.2023.109296
dc.identifier.citationClinical Immunology, v. 250.
dc.identifier.doi10.1016/j.clim.2023.109296
dc.identifier.issn1521-7035
dc.identifier.issn1521-6616
dc.identifier.scopus2-s2.0-85151278990
dc.identifier.urihttp://hdl.handle.net/11449/248598
dc.language.isoeng
dc.relation.ispartofClinical Immunology
dc.sourceScopus
dc.subjectChildhood-SLE
dc.subjectcLLDAS
dc.subjectcSLE
dc.subjectLow disease activity
dc.subjectT2T
dc.subjectTreat-to-target
dc.titlePReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS)en
dc.typeArtigo

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