Ureasil-polyether hybrid blend with tuneable hydrophilic/hydrophobic features based on U-PEO1900 and U-PPO400 mixtures

Página do item simplificado
dc.contributor.authorMolina, Eduardo F. [UNESP]
dc.contributor.authorNogueira Jesus, Celso R. [UNESP]
dc.contributor.authorChiavacci, Leila A. [UNESP]
dc.contributor.authorPulcinelli, Sandra Helena [UNESP]
dc.contributor.authorBriois, Valerie
dc.contributor.authorSantilli, Celso Valentim [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSynchrotron SOLEIL LOrme des Merisiers
dc.date.accessioned2014-12-03T13:08:38Z
dc.date.available2014-12-03T13:08:38Z
dc.date.issued2014-05-01
dc.description.abstractUrea-cross-linked polyether-siloxane hybrid blends with tuneable hydrophilic/hydrophobic features were prepared from a mixture of poly(ethylene oxide) (PEO1900) and poly(propylene oxide) (PPO400), hybridized by end-chain functionalization with (3-isocyanatopropyl)triethoxysilane. The aim of this study was to demonstrate that the combination of the different polyether phases produces materials with hydrophilic and hydrophobic properties. An anti-fog coating and a transparent monolithic swellable hydrogel were produced from the PEO1900 hybrid. Swellability and drug release profiles could be easily tuned by varying the ureasil-PEO/ureasil-PPO ratio in the hybrid matrix. Differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS) analyses indicated that the nanostructure of the hybrid blends could be described by the existence of a biphasic mixture of PEO1900-rich and PPO400-rich phases, with a fraction of the lamellar domains being derived from the PEO1900 crystallinity. A correlation between the nanoscopic features and the kinetics of the swelling mechanism is proposed, based on the results of in situ SAXS analyses. In vitro monitoring using UV-Vis spectroscopy indicated that the kinetics of drug release from the PEO1900:PPO400 hybrid blends could be controlled by varying the proportions of the hydrophilic (PEO1900) and hydrophobic (PPO400) hybrids. The response to pH change and to application of a magnetic field to the PEO1900-magnetite nanocomposite indicated that the production of stimuli-responsive delivery devices based on ureasil-PE should be feasible in the near future.en
dc.description.affiliationUNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationSynchrotron SOLEIL LOrme des Merisiers, F-91192 Gif Sur Yvette, France
dc.description.affiliationUNESP, Sch Pharmaceut Sci, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Pharmaceut Sci, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFrench agency COFECUB
dc.description.sponsorshipSOLEIL (France)
dc.description.sponsorshipLNLS (Brazil)
dc.description.sponsorshipIdFrench agency COFECUBPh. 564/07
dc.format.extent317-328
dc.identifierhttp://dx.doi.org/10.1007/s10971-014-3300-1
dc.identifier.citationJournal Of Sol-gel Science And Technology. Dordrecht: Springer, v. 70, n. 2, p. 317-328, 2014.
dc.identifier.doi10.1007/s10971-014-3300-1
dc.identifier.issn0928-0707
dc.identifier.lattes9971202585286967
dc.identifier.lattes5584298681870865
dc.identifier.orcid0000-0002-8356-8093
dc.identifier.urihttp://hdl.handle.net/11449/111424
dc.identifier.wosWOS:000335639600020
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Sol-Gel Science and Technology
dc.relation.ispartofjcr1.745
dc.relation.ispartofsjr0,477
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectUreasil-polyether hybridsen
dc.subjectPEO: PPO blenden
dc.subjectDrug deliveryen
dc.subjectSwellingen
dc.subjectAnti-fog coatingen
dc.titleUreasil-polyether hybrid blend with tuneable hydrophilic/hydrophobic features based on U-PEO1900 and U-PPO400 mixturesen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes9971202585286967
unesp.author.lattes5584298681870865[6]
unesp.author.orcid0000-0002-8356-8093[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

Arquivos

Coleções

Artigos - Físico Química - IQ