Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs

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dc.contributor.authorCampagnol, Daniela [UNESP]
dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorMonteiro, Eduardo R. [UNESP]
dc.contributor.authorRestitutti, Flavia [UNESP]
dc.contributor.authorMinto, Bruno W. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:52Z
dc.date.available2014-05-20T15:32:52Z
dc.date.issued2012-07-01
dc.description.abstractObjective To compare the effect of intraperitoneal (IP) or incisional (INC) bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs.Study design Prospective, randomized clinical study.Animals Thirty female dogs undergoing ovariohysterectomy (OHE).Methods Dogs admitted for elective OHE were anesthetized with acepromazine, butorphanol, thiopental and halothane. Animals were randomly assigned to one of three groups (n = 10 per group). The treatments consisted of preincisional infiltration with saline solution (NaCl 0.9%) or bupivacaine with epinephrine and/or IP administration of the same solutions, as follows: INC and IP 0.9% NaCl (control group); INC 0.9% NaCl and IP bupivacaine (5 mg kg(-1), IP group); INC bupivacaine (1 mg kg(-1)) and IP 0.9% NaCl (INC group). Postoperative pain was evaluated by a blinded observer for 24 hours after extubation by means of a visual analog scale (VAS) and a numeric rating scale (NRS). Rescue analgesia (morphine, 0.5 mg kg(-1), IM) was administered if the VAS was > 5/10 or the NRS > 10/29.Results At 1 hour after anesthesia, VAS pain scores were [medians (interquartile range)]: 6.4 (3.1-7.9), 0.3 (0.0-2.6) and 0.0 (0.0-7.0) in control, IP and INC groups, respectively. VAS pain scores were lower in the IP compared to the control group. Over the first 24 hours, rescue analgesia was administered to 7/10, 5/10 and 3/10 dogs of the control, INC and IP groups, respectively. Total number of dogs given rescue analgesia over the first 24 hours did not differ significantly among groups.Conclusions and clinical relevance Intraperitoneal bupivacaine resulted in lower pain scores during the first hour of the postoperative period and there was a trend towards a decreased need for rescue analgesia after OHE in dogs.en
dc.description.affiliationUniv Estadual Paulista, Dept Cirurgia & Anestesiol Vet, Fac Med Vet & Zootecnia, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Cirurgia & Anestesiol Vet, Fac Med Vet & Zootecnia, São Paulo, Brazil
dc.format.extent426-430
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2012.00728.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Hoboken: Wiley-blackwell, v. 39, n. 4, p. 426-430, 2012.
dc.identifier.doi10.1111/j.1467-2995.2012.00728.x
dc.identifier.issn1467-2987
dc.identifier.urihttp://hdl.handle.net/11449/41658
dc.identifier.wosWOS:000305514100014
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbupivacaineen
dc.subjectcanineen
dc.subjectlocal anestheticsen
dc.subjectpostoperative painen
dc.subjectregional anesthesiaen
dc.titleEffect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes0131201084614247[5]
unesp.author.orcid0000-0002-3002-8093[2]
unesp.author.orcid0000-0002-5288-3998[4]
unesp.author.orcid0000-0002-8808-4127[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Cirurgia e Anestesiologia Veterinária - FMVZ