Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate

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dc.contributor.authorPrezotti, Fabiola Garavello [UNESP]
dc.contributor.authorMeneguin, Andreia Bagliotti [UNESP]
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.authorCury, Beatriz Stringhetti Ferreira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:51Z
dc.date.available2014-05-20T13:24:51Z
dc.date.issued2012-11-01
dc.description.abstractHigh amylose and pectin were mixed at 1: 1 mass ratio and cross-linked with sodium trimetaphosphate (STMP) in alkaline medium. Films were prepared from aqueous dispersions of these cross-linked polymer blend at three different concentrations (3, 4 and 5%), by solvent casting method. Characterization of the films included thickness, surface morphology, water uptake, water vapor permeability (WVP), tensile strength measurements and enzymatic digestion. The cross-linking allowed to obtain films with improved mechanical properties and reduced WVP. The high resistance to enzymatic digestion exhibited by these films represents a promising approach to their application in the development of colon drug delivery systems.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Drugs & Pharmaceut, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Grad Program Pharmaceut Sci, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Drugs & Pharmaceut, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Grad Program Pharmaceut Sci, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1354-1359
dc.identifierhttp://dx.doi.org/10.3109/03639045.2011.650863
dc.identifier.citationDrug Development and Industrial Pharmacy. London: Informa Healthcare, v. 38, n. 11, p. 1354-1359, 2012.
dc.identifier.doi10.3109/03639045.2011.650863
dc.identifier.issn0363-9045
dc.identifier.lattes5361569184579557
dc.identifier.urihttp://hdl.handle.net/11449/7819
dc.identifier.wosWOS:000309453100009
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.relation.ispartofjcr1.883
dc.relation.ispartofsjr0,519
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectThicknessen
dc.subjectwater uptakeen
dc.subjectwater vapor permeabilityen
dc.subjectmechanical propertiesen
dc.subjectcontrolled releaseen
dc.subjectcolonen
dc.titlePreparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphateen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes5361569184579557
unesp.author.orcid0000-0002-8337-7991[1]
unesp.author.orcid0000-0003-3020-9238[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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