Effect of micelles, microemulsions and other supramolecular aggregates on the hydrolysis of β-lactam antibiotics

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dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.authorScarpa, M. V. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:51Z
dc.date.available2014-05-27T11:19:51Z
dc.date.issued1999-12-01
dc.description.abstractA critical revision of the literature was made regarding the stability of β-lactam antibiotics in the presence of surfactants. The factors involved in the drug decomposition were analyzed in the development of the discussion. The analysis has indicated that some organized systems obtained from surfactants can be used to control rates and mechanisms of antibiotic decomposition. These organized systems can also be used to obtain specific information about the drug reactivity in a microenvironment similar to the site of pharmacological effect.en
dc.description.affiliationDepto. de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas UNESP, 14801-902 - Araraquara - SP
dc.description.affiliationUnespDepto. de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas UNESP, 14801-902 - Araraquara - SP
dc.format.extent35-47
dc.identifier.citationRevista de Ciencias Farmaceuticas, v. 20, n. 1, p. 35-47, 1999.
dc.identifier.issn0101-3793
dc.identifier.lattes9114495952533044
dc.identifier.scopus2-s2.0-0033381749
dc.identifier.urihttp://hdl.handle.net/11449/66022
dc.language.isoeng
dc.relation.ispartofRevista de Ciencias Farmaceuticas
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectβ-lactam antibiotics
dc.subjectDrug decomposition
dc.subjectMicelles
dc.subjectMicroemulsions
dc.subjectSurfactants
dc.subjectamoxicillin
dc.subjectampicillin
dc.subjectbeta lactam antibiotic
dc.subjectcefaclor
dc.subjectcefadroxil
dc.subjectcefalexin
dc.subjectcefazolin
dc.subjectcefradine
dc.subjectcephalosporin derivative
dc.subjectcetrimide
dc.subjectdodecyl sulfate sodium
dc.subjectpenicillin derivative
dc.subjectpenicillin G
dc.subjectpolidocanol
dc.subjectpropicillin
dc.subjectsurfactant
dc.subjectdrug decomposition
dc.subjectdrug hydrolysis
dc.subjectdrug stability
dc.subjectdrug structure
dc.subjectionic strength
dc.subjectmicelle
dc.subjectmicroemulsion
dc.subjectpH
dc.subjectreview
dc.titleEffect of micelles, microemulsions and other supramolecular aggregates on the hydrolysis of β-lactam antibioticsen
dc.typeResenha
unesp.author.lattes9114495952533044[1]
unesp.author.orcid0000-0002-0107-9940[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR