Stress vulnerability during adolescence

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dc.contributor.authorDuarte, Josiane O.
dc.contributor.authorCruz, Fábio C.
dc.contributor.authorLeão, Rodrigo M.
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-06T16:13:51Z
dc.date.available2015-08-06T16:13:51Z
dc.date.issued2015
dc.description.abstractObjective: This study investigated the physiological and somatic changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in adolescent and adult rats, with a focus on cardiovascular function. The long-term effects of stress exposure during adolescence were also investigated longitudinally. Methods: Male Wistar rats were exposed to repeated restraint stress (RRS, homotypic) or chronic variable stress (CVS, heterotypic). Results: Adrenal hypertrophy, thymus involution, and elevated plasma glucocorticoid were observed only in adolescent animals, whereas reduction in body weight was caused by both stress regimens in adults. CVS increased mean arterial pressure (adolescent: p = .001; adult: p = .005) and heart rate (HR; adolescent: p = .020; adult: p = .011) regardless of the age, whereas RRS increased blood pressure selectively in adults (p = .001). Rest tachycardia evoked by CVS was associated with increased cardiac sympathetic activity in adults, whereas a decreased cardiac parasympathetic activity was observed in adolescent animals. Changes in cardiovascular function and cardiac autonomic activity evoked by both CVS and RRS were followed by alterations in baroreflex activity and vascular reactivity to vasoconstrictor and vasodilator agents in adolescent adult animals. Except for the circulating glucocorticoid change, all alterations observed during adolescence were reversed in adulthood. Conclusions: These findings suggest a stress vulnerability of adolescents to somatic and neuroendocrine effects regardless of stress regimen. Our results indicated an age-stress type-specific influence in stress-evoked cardiovascular/autonomic changes. Data suggest minimal consequences in adulthood of stress during adolescence.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.format.extent186-199
dc.identifierhttp://pt.wkhealth.com/pt/re/lwwgateway/landingpage.htm;jsessionid=VwyTM6pYJKsnQXcLWSLM0vzX2CQQL0NM92g6LkNxJTxlRXx8wYL5!-93748135!181195629!8091!-1?sid=WKPTLP:landingpage&an=00006842-201502000-00010
dc.identifier.citationPsychosomatic Medicine, v. 77, n. 2, p. 186-199, 2015.
dc.identifier.doi10.1097/psy.0000000000000141
dc.identifier.issn0033-3174
dc.identifier.lattes2514762545280942
dc.identifier.lattes1117432571971568
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/126066
dc.language.isoeng
dc.relation.ispartofPsychosomatic Medicine
dc.relation.ispartofjcr3.810
dc.relation.ispartofsjr2,001
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleStress vulnerability during adolescenceen
dc.typeArtigo
unesp.author.lattes1117432571971568[5]
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-1942-858X[5]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologiapt

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