Influence of growth rate and length on fluoride detection in human nails

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dc.contributor.authorBuzalaf, M. A. R.
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorAlves, K. M. R. P.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:24:32Z
dc.date.available2014-05-20T15:24:32Z
dc.date.issued2006-01-01
dc.description.abstractThis study aimed to determine the lag time between increased fluoride (F) intake and F detection in human nails, as well as the influence of nails growth rate and length on this. Ten 20- to 35-year-old volunteers received 1.8 mg F daily, for 30 days. Nail growth rate and length were determined for all fingernails and toenails. Nail samples were collected at the beginning of the study and every 2 weeks (15 collections in all) and F concentrations were determined. The growth rate was statistically higher in fingernails than in toenails. No statistically significant differences were observed between right and left sides. Growth rate was significantly greater for big toenails than for the other toenails, but this pattern was not found for fingernails. The estimated mean lag times for F detection in fingernails and toenails were 101 and 123 days, respectively. An apparent increase in fingernail F concentrations was observed 84 days after the beginning of the study, although this was not statistically different from baseline. For toenails, statistically significant increases in F concentration in relation to baseline were observed 112 and 140 days after increased F ingestion. These increases occurred within the 95% confidence intervals for the calculated mean lag time for fluoride detection in nails. Considering the large amount of sample provided by the big toenails, together with their faster growth rate, as well as the fact that toenails are less prone to environmental contamination, our data suggest that big toenails are more suitable biomarkers of fluoride intake.en
dc.description.affiliationUniv São Paulo, Bauru Dent Sch, Dept Biol Sci, Bauru, Brazil
dc.description.affiliationUniv São Paulo, Bauru Dent Sch, Dept Pediat Dent Orthodont & Publ Hlth, Bauru, Brazil
dc.description.affiliationSau Paulo State Univ, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, São Paulo State University, Araçatuba, SP, Brazil
dc.format.extent231-238
dc.identifierhttp://dx.doi.org/10.1159/000092231
dc.identifier.citationCaries Research. Basel: Karger, v. 40, n. 3, p. 231-238, 2006.
dc.identifier.doi10.1159/000092231
dc.identifier.issn0008-6568
dc.identifier.urihttp://hdl.handle.net/11449/35124
dc.identifier.wosWOS:000237697700009
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCaries Research
dc.relation.ispartofjcr2.188
dc.relation.ispartofsjr1,108
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbiomarkerspt
dc.subjectdietpt
dc.subjectfluoride in nailspt
dc.subjecturinept
dc.titleInfluence of growth rate and length on fluoride detection in human nailsen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Infantil e Social - FOA